• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

中国卒中协会科学声明:急性缺血性脑卒中的静脉溶栓治疗。

The Chinese Stroke Association scientific statement: intravenous thrombolysis in acute ischaemic stroke.

机构信息

Department of Neurology, Huashan Hospital affiliated to Fudan University, Shanghai Shi, China.

Department of Neurology, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing, China.

出版信息

Stroke Vasc Neurol. 2017 Jun 2;2(3):147-159. doi: 10.1136/svn-2017-000074. eCollection 2017 Sep.

DOI:10.1136/svn-2017-000074
PMID:28989804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5628383/
Abstract

The most effective medical treatment for acute ischaemic stroke (AIS) is to offer intravenous thrombolysis during the ultra-early period of time after the onset. Even based on the Consensus of Chinese Experts on Intravenous Thrombolysis for AIS in 2012 and 2014 Chinese Guidelines on the Diagnosis and Treatment of AIS, the rate of thrombolysis for AIS in China remained around 2.4%, and the rate of intravenous tissue plasminogen activator usage was only about 1.6% in real world. The indication of thrombolysis for AIS has been expanded, and contraindications have been reduced with recently published studies. In order to facilitate the standardisation of treating AIS, improve the rate of thrombolysis and benefit patients who had a stroke, Chinese Stroke Association has organised and developed this scientific statement.

摘要

急性缺血性脑卒中(AIS)最有效的治疗方法是在发病后的超早期进行静脉溶栓治疗。即使基于 2012 年和 2014 年中国专家关于 AIS 静脉溶栓治疗的共识以及中国 AIS 诊断和治疗指南,中国 AIS 的溶栓率仍维持在 2.4%左右,实际应用中静脉使用组织型纤溶酶原激活剂的比例仅为 1.6%左右。最近的研究已经扩大了 AIS 溶栓的适应证,减少了禁忌证。为了促进 AIS 的规范化治疗,提高溶栓率,使卒中患者受益,中国卒中学会组织编写了本科学声明。

相似文献

1
The Chinese Stroke Association scientific statement: intravenous thrombolysis in acute ischaemic stroke.中国卒中协会科学声明:急性缺血性脑卒中的静脉溶栓治疗。
Stroke Vasc Neurol. 2017 Jun 2;2(3):147-159. doi: 10.1136/svn-2017-000074. eCollection 2017 Sep.
2
Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset.多模态 MRI 引导下静脉溶栓治疗起病时间不明的脑卒中患者的结局。
Stroke Vasc Neurol. 2019 Feb 11;4(1):3-7. doi: 10.1136/svn-2018-000151. eCollection 2019 Mar.
3
Stroke Thrombolysis in Patients Taking Ticagrelor -Two Successful Cases and a Review of the Literature.替格瑞洛治疗的缺血性脑卒中溶栓治疗-两例成功病例并文献复习
J Stroke Cerebrovasc Dis. 2021 Feb;30(2):105520. doi: 10.1016/j.jstrokecerebrovasdis.2020.105520. Epub 2020 Dec 10.
4
Low-dose intravenous tissue plasminogen activator for acute ischaemic stroke: an alternative or a new standard?急性缺血性脑卒中的小剂量静脉注射组织型纤溶酶原激活物:替代治疗还是新标准?
Stroke Vasc Neurol. 2016 Oct 25;1(3):115-121. doi: 10.1136/svn-2016-000033. eCollection 2016 Sep.
5
Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial.《ENCHANTED 试验中中国与非中国参与者的特点、管理和阿替普酶治疗反应》
Stroke Vasc Neurol. 2017 May 22;2(2):53-58. doi: 10.1136/svn-2017-000085. eCollection 2017 Jun.
6
Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours (HOPE): protocol for a randomised, controlled, multicentre study.发病 4.5 至 24 小时的缺血性脑卒中患者静脉内使用重组组织型纤溶酶原激活剂(alteplase)治疗(HOPE):一项随机、对照、多中心研究的方案。
Stroke Vasc Neurol. 2024 Jun 21;9(3):318-323. doi: 10.1136/svn-2022-002154.
7
Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective.在 MRI DWI/T2WI 不匹配的指导下,对发病超过 4.5 小时的缺血性中风患者进行静脉 tPA 治疗是安全有效的。
Stroke Vasc Neurol. 2019 Feb 11;4(1):8-13. doi: 10.1136/svn-2018-000186. eCollection 2019 Mar.
8
Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis.急性缺血性脑卒中伴隐匿性感染性心内膜炎患者的静脉溶栓治疗。
J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105502. doi: 10.1016/j.jstrokecerebrovasdis.2020.105502. Epub 2020 Dec 23.
9
Efficacy and safety of intravenous thrombolysis with alteplase for treating acute ischemic stroke at different time windows: A protocol for systematic review and meta-analysis.阿替普酶静脉溶栓治疗不同时间窗急性缺血性脑卒中的有效性和安全性的系统评价和荟萃分析方案。
Medicine (Baltimore). 2020 Dec 24;99(52):e23620. doi: 10.1097/MD.0000000000023620.
10
Shenzhen stroke emergency map improves access to rt-PA for patients with acute ischaemic stroke.深圳脑卒中急救地图提高急性缺血性脑卒中患者接受 rt-PA 治疗的机会。
Stroke Vasc Neurol. 2019 Jun 21;4(3):115-122. doi: 10.1136/svn-2018-000212. eCollection 2019 Sep.

引用本文的文献

1
A similar effect of fibrinogen on efficacy and safety of tenecteplase alteplase in acute ischemic cerebrovascular events (TRACE II) trial.纤维蛋白原对替奈普酶与阿替普酶治疗急性缺血性脑血管事件疗效和安全性影响的相似性(TRACE II)试验
J Transl Int Med. 2025 Apr 18;13(3):295-303. doi: 10.1515/jtim-2025-0010. eCollection 2025 Jun.
2
Decomposing door-to-needle time: insights into workflow delays and quality improvement in acute stroke care.剖析门到针时间:洞察急性卒中护理中的工作流程延误与质量改进
Front Neurol. 2025 Aug 1;16:1651785. doi: 10.3389/fneur.2025.1651785. eCollection 2025.
3
Association between glucose-to-albumin ratio and ischemic stroke risk in patients with coronary heart disease: a machine learning-based predictive model analysis.冠心病患者血糖与白蛋白比值和缺血性中风风险之间的关联:基于机器学习的预测模型分析
BMC Cardiovasc Disord. 2025 Jul 25;25(1):544. doi: 10.1186/s12872-025-04927-x.
4
Head-to-Head: Recombinant Human Prourokinase Versus Intravenous Thrombolytics in Acute Ischemic Stroke Within 4.5 Hours - A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials.头对头比较:重组人尿激酶原与静脉溶栓药物用于4.5小时内急性缺血性卒中的疗效——一项随机临床试验的系统评价和网状Meta分析
Clin Appl Thromb Hemost. 2025 Jan-Dec;31:10760296251334563. doi: 10.1177/10760296251334563. Epub 2025 Apr 24.
5
Expression and clinical significance of 25-hydroxyvitamin D, insulin-like growth factor 1, and beta-2 microglobulin in cognitive dysfunction after ischemic stroke in the elderly.25-羟基维生素D、胰岛素样生长因子1及β2微球蛋白在老年缺血性脑卒中后认知功能障碍中的表达及临床意义
Neuroreport. 2025 Feb 5;36(3):127-134. doi: 10.1097/WNR.0000000000002128. Epub 2025 Jan 6.
6
Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial.静脉注射尿激酶与最佳药物治疗对急性轻度中风患者功能结局的影响(TRUST):一项随机对照试验
BMC Med. 2025 Jan 6;23(1):6. doi: 10.1186/s12916-024-03820-2.
7
Albumin adjuvant therapy for acute ischemic stroke with large vessel occlusion (AMASS-LVO): rationale, design, and protocol for a phase 1, open-label, clinical trial.白蛋白辅助治疗急性大血管闭塞性缺血性卒中(AMASS-LVO):一项1期开放标签临床试验的原理、设计与方案
Front Neurol. 2024 Sep 30;15:1455388. doi: 10.3389/fneur.2024.1455388. eCollection 2024.
8
Efficacy and Safety of Intravenous Tenecteplase Versus Alteplase in Treating Acute Ischemic Stroke With Diabetes and Admission Hyperglycemia.静脉注射替奈普酶与阿替普酶治疗伴有糖尿病和入院高血糖的急性缺血性脑卒中的疗效和安全性。
J Am Heart Assoc. 2024 Oct 15;13(20):e036393. doi: 10.1161/JAHA.124.036393. Epub 2024 Oct 11.
9
Code Stroke Alert: Focus on Emergency Department Time Targets and Impact on Door-to-Needle Time across Day and Night Shifts.卒中代码警报:关注急诊科时间目标以及昼夜轮班对门到针时间的影响。
J Pers Med. 2024 Jun 2;14(6):596. doi: 10.3390/jpm14060596.
10
Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial.替奈普酶与阿替普酶用于老年急性缺血性卒中患者的疗效比较:TRACE-2试验的事后分析
Stroke Vasc Neurol. 2025 Feb 25;10(1):112-119. doi: 10.1136/svn-2023-003048.

本文引用的文献

1
Stroke 1-2-0: a rapid response programme for stroke in China.中风1-2-0:中国的一项中风快速反应计划。
Lancet Neurol. 2017 Jan;16(1):27-28. doi: 10.1016/S1474-4422(16)30283-6. Epub 2016 Oct 28.
2
Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial.机械取栓联合静脉溶栓与单纯静脉溶栓治疗急性缺血性脑卒中的随机对照研究(THRACE)
Lancet Neurol. 2016 Oct;15(11):1138-47. doi: 10.1016/S1474-4422(16)30177-6. Epub 2016 Aug 23.
3
Safety and Outcome of Intra-Arterial Treatment for Basilar Artery Occlusion.基底动脉闭塞的动脉内治疗的安全性和结果。
JAMA Neurol. 2016 Oct 1;73(10):1225-1230. doi: 10.1001/jamaneurol.2016.1408.
4
Aspiration Thrombectomy After Intravenous Alteplase Versus Intravenous Alteplase Alone.静脉注射阿替普酶后进行抽吸血栓切除术与单纯静脉注射阿替普酶的比较。
Stroke. 2016 Sep;47(9):2331-8. doi: 10.1161/STROKEAHA.116.013372. Epub 2016 Aug 2.
5
Incidence and Predictors of Early Recanalization After Intravenous Thrombolysis: A Systematic Review and Meta-Analysis.静脉溶栓后早期再通的发生率及预测因素:一项系统评价和Meta分析
Stroke. 2016 Sep;47(9):2409-12. doi: 10.1161/STROKEAHA.116.014181. Epub 2016 Jul 26.
6
Recognition of Stroke by EMS is Associated with Improvement in Emergency Department Quality Measures.急救医疗服务(EMS)对中风的识别与急诊科质量指标的改善相关。
Prehosp Emerg Care. 2016 Nov-Dec;20(6):729-736. doi: 10.1080/10903127.2016.1182602. Epub 2016 May 31.
7
Early neurological deterioration after thrombolysis: Clinical and imaging predictors.溶栓后早期神经功能恶化:临床和影像学预测因素。
Int J Stroke. 2016 Oct;11(7):776-82. doi: 10.1177/1747493016650454. Epub 2016 May 17.
8
A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator Administration.组织型纤溶酶原激活剂给药后口咽血管性水肿治疗的新方法。
Ann Emerg Med. 2016 Sep;68(3):345-8. doi: 10.1016/j.annemergmed.2016.02.019. Epub 2016 May 10.
9
Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.低剂量与标准剂量静脉内阿替普酶治疗急性缺血性脑卒中。
N Engl J Med. 2016 Jun 16;374(24):2313-23. doi: 10.1056/NEJMoa1515510. Epub 2016 May 10.
10
Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis.血管内治疗与单纯药物治疗对缺血性卒中的疗效比较:系统评价与荟萃分析
BMJ. 2016 Apr 18;353:i1754. doi: 10.1136/bmj.i1754.