用于生物制剂递送的基于肽的超分子水凝胶
Peptide-Based Supramolecular Hydrogels for Delivery of Biologics.
作者信息
Li Yi, Wang Feihu, Cui Honggang
机构信息
Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
出版信息
Bioeng Transl Med. 2016 Sep;1(3):306-322. doi: 10.1002/btm2.10041.
The demand for therapeutic biologics has rapidly grown over recent decades, creating a dramatic shift in the pharmaceutical industry from small molecule drugs to biological macromolecular therapeutics. As a result of their large size and innate instability, the systemic, topical, and local delivery of biologic drugs remains a highly challenging task. Although there exist many types of delivery vehicles, peptides and peptide conjugates have received continuously increasing interest as molecular blocks to create a great diversity of supramolecular nanostructures and hydrogels for the effective delivery of biologics, due to their inherent biocompatibility, tunable biodegradability, and responsiveness to various biological stimuli. In this context, we discuss the design principles of supramolecular hydrogels using small molecule peptides and peptide conjugates as molecular building units, and review the recent effort in using these materials for protein delivery and gene delivery.
近几十年来，对治疗性生物制品的需求迅速增长，使制药行业从小分子药物向生物大分子疗法发生了巨大转变。由于生物药物体积大且固有稳定性差，其全身、局部和局部递送仍然是一项极具挑战性的任务。尽管存在多种类型的递送载体，但肽和肽缀合物作为分子模块，用于构建多种多样的超分子纳米结构和水凝胶以有效递送生物制品，因其固有的生物相容性、可调节的生物降解性以及对各种生物刺激的响应性，受到了越来越多的关注。在此背景下，我们讨论了以小分子肽和肽缀合物作为分子构建单元的超分子水凝胶的设计原则，并综述了近年来将这些材料用于蛋白质递送和基因递送的研究进展。
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