• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

可见光促进的γ-氰基烷基自由基生成：未活化烯烃的三组分氰基丙基化/醚化反应

Visible-light promoted γ-cyanoalkyl radical generation: three-component cyanopropylation/etherification of unactivated alkenes.

作者信息

Li Linyong, Chen Haoguo, Mei Mingjing, Zhou Lei

机构信息

School of Chemistry, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.

出版信息

Chem Commun (Camb). 2017 Oct 19;53(84):11544-11547. doi: 10.1039/c7cc07347j.

DOI:10.1039/c7cc07347j
PMID:28990024
Abstract

A photoredox approach to generate distal cyano-substituted alkyl radicals through C-C bond cleavage of cyclobutanone oximes was developed. The radicals produced by this method were applied to three-component cyanopropylation/etherification of unactivated alkenes. Their reactions with diverse radical acceptors were also demonstrated.

摘要

开发了一种光氧化还原方法，通过环丁酮肟的C-C键裂解生成远端氰基取代的烷基自由基。该方法产生的自由基应用于未活化烯烃的三组分氰基丙基化/醚化反应。还展示了它们与各种自由基受体的反应。

相似文献

1
Visible-light promoted γ-cyanoalkyl radical generation: three-component cyanopropylation/etherification of unactivated alkenes.可见光促进的γ-氰基烷基自由基生成：未活化烯烃的三组分氰基丙基化/醚化反应
Chem Commun (Camb). 2017 Oct 19;53(84):11544-11547. doi: 10.1039/c7cc07347j.
2
A Visible-Light-Driven Iminyl Radical-Mediated C-C Single Bond Cleavage/Radical Addition Cascade of Oxime Esters.可见光照驱动的亚胺基自由基介导的肟酯 C-C 单键断裂/自由基加成级联反应。
Angew Chem Int Ed Engl. 2018 Jan 15;57(3):738-743. doi: 10.1002/anie.201710618. Epub 2017 Dec 18.
3
Recent advances in ring-opening of cyclobutanone oximes for capturing SO, CO or O a radical process.用于捕获SO、CO或O的环丁酮肟开环反应的最新进展——一种自由基过程。
Org Biomol Chem. 2023 Dec 20;22(1):10-24. doi: 10.1039/d3ob01762a.
4
Copper-Catalyzed Intermolecular Heck-Like Coupling of Cyclobutanone Oximes Initiated by Selective C-C Bond Cleavage.铜催化的环丁酮肟的分子间 Heck 型偶联反应：通过选择性 C-C 键断裂引发。
Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12727-12731. doi: 10.1002/anie.201707181. Epub 2017 Sep 1.
5
Carboamination of Unactivated Alkenes through Three-Component Radical Conjugate Addition.通过三组分自由基共轭加成实现未活化烯烃的碳氨基化反应。
Angew Chem Int Ed Engl. 2019 Nov 11;58(46):16528-16532. doi: 10.1002/anie.201910926. Epub 2019 Oct 11.
6
β-Lactam Synthesis via Copper-Catalyzed Directed Aminoalkylation of Unactivated Alkenes with Cyclobutanone -Benzoyloximes.铜催化的未活化烯烃与环丁酮-苯甲肟的定向氨基烷基化合成β-内酰胺。
Org Lett. 2021 May 7;23(9):3620-3625. doi: 10.1021/acs.orglett.1c01007. Epub 2021 Apr 14.
7
Copper-catalyzed intermolecular carboetherification of unactivated alkenes by alkyl nitriles and alcohols.铜催化的未活化烯烃与烷基腈和醇的分子间碳醚化反应。
Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5443-6. doi: 10.1002/anie.201412357. Epub 2015 Mar 3.
8
Transition-Metal-Free Three-Component Radical 1,2-Amidoalkynylation of Unactivated Alkenes.无过渡金属参与的自由基三组分 1,2-氨基炔基化反应。
Chemistry. 2019 Jan 7;25(2):516-520. doi: 10.1002/chem.201805490. Epub 2018 Dec 11.
9
Cyano-Fluorosulfonylation of Unactivated Alkenes by Photoredox and Copper Dual Catalysis.光氧化还原与铜双催化实现未活化烯烃的氰基氟磺酰化反应
Org Lett. 2024 Oct 25;26(42):9132-9137. doi: 10.1021/acs.orglett.4c03495. Epub 2024 Oct 16.
10
Directing-Group-Based Strategy Enabling Intermolecular Heck-Type Reaction of Cycloketone Oxime Esters and Unactivated Alkenes.基于导向基团的策略实现环酮肟酯与非活化烯烃的分子间 Heck 型反应。
Org Lett. 2020 May 1;22(9):3524-3530. doi: 10.1021/acs.orglett.0c00963. Epub 2020 Apr 15.

引用本文的文献

1
Aromatization-driven deconstructive functionalization of spiro dihydroquinazolinones dual photoredox/nickel catalysis.基于芳构化驱动的螺二氢喹唑啉酮的解构官能团化：双光氧化还原/镍催化
Chem Sci. 2024 May 8;15(23):8993-8999. doi: 10.1039/d4sc01111b. eCollection 2024 Jun 12.
2
γ-Amino Alcohols via Energy Transfer Enabled Brook Rearrangement.通过能量转移实现的布鲁克重排合成γ-氨基醇
J Am Chem Soc. 2024 Apr 17;146(15):10899-10907. doi: 10.1021/jacs.4c01667. Epub 2024 Apr 3.
3
Synthesis of aliphatic nitriles from cyclobutanone oxime mediated by sulfuryl fluoride (SOF).
由硫酰氟（SOF）介导，从环丁酮肟合成脂肪腈。
Beilstein J Org Chem. 2023 Jun 22;19:901-908. doi: 10.3762/bjoc.19.68. eCollection 2023.
4
Synthesis and Application Dichalcogenides as Radical Reagents with Photochemical Technology.二硫属化物作为自由基试剂的合成及应用与光化学技术。
Molecules. 2023 Feb 20;28(4):1998. doi: 10.3390/molecules28041998.
5
Aryl Transfer Strategies Mediated by Photoinduced Electron Transfer.芳基转移策略介导的光致电子转移。
Chem Rev. 2022 Jan 26;122(2):2695-2751. doi: 10.1021/acs.chemrev.1c00388. Epub 2021 Oct 21.
6
Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis.氮中心自由基的生成策略可能依赖于光氧化还原催化：反应方法的发展及其在有机合成中的应用。
Chem Rev. 2022 Jan 26;122(2):2353-2428. doi: 10.1021/acs.chemrev.1c00444. Epub 2021 Oct 8.
7
Photoinduced 1,2-dicarbofunctionalization of alkenes with organotrifluoroborate nucleophiles radical/polar crossover.烯烃与有机三氟硼酸盐亲核试剂的光诱导1,2-二碳官能化：自由基/极性交叉反应
Chem Sci. 2021 Jun 7;12(26):9189-9195. doi: 10.1039/d1sc02547c. eCollection 2021 Jul 7.
8
Photoredox-Mediated Net-Neutral Radical/Polar Crossover Reactions.光氧化还原介导的净中性自由基/极性交叉反应。
Isr J Chem. 2020 Mar;60(3-4):281-293. doi: 10.1002/ijch.201900166. Epub 2020 Feb 18.
9
Recent Advances in Photoredox-Mediated Radical Conjugate Addition Reactions: An Expanding Toolkit for the Giese Reaction.光氧化还原介导的自由基共轭加成反应的最新进展：吉泽反应的扩展工具包
Angew Chem Int Ed Engl. 2021 Sep 20;60(39):21116-21149. doi: 10.1002/anie.202016666. Epub 2021 Jul 21.
10
A dual photoredox-nickel strategy for remote functionalization iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades.一种用于远程官能团化亚胺基自由基的双光氧化还原-镍策略：自由基开环-芳基化、-乙烯基化和-烷基化串联反应。
Chem Sci. 2019 Jun 27;10(33):7728-7733. doi: 10.1039/c9sc02616a. eCollection 2019 Sep 7.