• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

源自南极海洋真菌皮壳青霉HDN153086的次生代谢产物。

Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086.

作者信息

Liu Cong-Cong, Zhang Zhen-Zhen, Feng Yan-Yan, Gu Qian-Qun, Li De-Hai, Zhu Tian-Jiao

机构信息

a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.

b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao , P. R. China.

出版信息

Nat Prod Res. 2019 Feb;33(3):414-419. doi: 10.1080/14786419.2018.1455045. Epub 2018 Mar 30.

DOI:10.1080/14786419.2018.1455045
PMID:29600717
Abstract

A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC value of 12.7 μM.

摘要

从南极海洋来源的真菌 crustosum HDN153086 中分离出一种新的多烯化合物（1）和一种新的二酮哌嗪（2），以及三种已知化合物（3 - 5）。通过质谱（MS）、核磁共振（NMR）和特定电子圆二色光谱（ECD）的含时密度泛函理论（TD - DFT）计算推导了 1 - 5 的结构。评估了这些化合物对 K562 细胞系的细胞毒性活性，只有化合物 2 对 K562 细胞表现出细胞毒性，IC 值为 12.7 μM。

相似文献

1
Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086.源自南极海洋真菌皮壳青霉HDN153086的次生代谢产物。
Nat Prod Res. 2019 Feb;33(3):414-419. doi: 10.1080/14786419.2018.1455045. Epub 2018 Mar 30.
2
Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005.海南吲哚，一种源自海洋青霉菌株KCB12F005的非同寻常的二酮哌嗪衍生物。
Bioorg Med Chem Lett. 2015 Nov 15;25(22):5398-401. doi: 10.1016/j.bmcl.2015.09.026. Epub 2015 Sep 10.
3
Brocazines A-F, Cytotoxic Bisthiodiketopiperazine Derivatives from Penicillium brocae MA-231, an Endophytic Fungus Derived from the Marine Mangrove Plant Avicennia marina.布罗考嗪 A-F，来自海洋红树林植物海桑内生真菌拟青霉 MA-231 的细胞毒双硫代二酮哌嗪衍生物。
J Nat Prod. 2014 Aug 22;77(8):1921-7. doi: 10.1021/np500382k.
4
Thiodiketopiperazines Produced by and Their Activities to Promote Gastrointestinal Motility.硫代二酮哌嗪类化合物的产生及其促进胃肠道动力的活性。
Molecules. 2019 Jan 15;24(2):299. doi: 10.3390/molecules24020299.
5
Citriperazines A-D produced by a marine algae-derived fungus sp. KMM 4672.海洋藻类来源真菌 sp. KMM 4672 产生的西替利嗪 A-D。
Nat Prod Res. 2020 Apr;34(8):1118-1123. doi: 10.1080/14786419.2018.1552696. Epub 2019 Jan 19.
6
Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.青霉环肽A-E，五种源自海洋内生真菌布罗卡青霉的新型硫化二酮哌嗪。
Mar Drugs. 2015 Jan 7;13(1):276-87. doi: 10.3390/md13010276.
7
Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum.南极嗜冷真菌 Oidiodendron truncatum 的细胞毒性代谢产物。
J Nat Prod. 2012 May 25;75(5):920-7. doi: 10.1021/np3000443. Epub 2012 May 14.
8
Absolute Configurations and Chitinase Inhibitions of Quinazoline-Containing Diketopiperazines from the Marine-Derived Fungus .海洋来源真菌中含喹唑啉二酮哌嗪的绝对构型和几丁质抑制作用。
Mar Drugs. 2020 Sep 21;18(9):479. doi: 10.3390/md18090479.
9
Furanone derivative and sesquiterpene from Antarctic marine-derived fungus Penicillium sp. S-1-18.来自南极海洋真菌青霉属菌株S-1-18的呋喃酮衍生物和倍半萜
J Asian Nat Prod Res. 2018 Dec;20(12):1108-1115. doi: 10.1080/10286020.2017.1385604. Epub 2017 Oct 9.
10
Peniciadametizine A, a Dithiodiketopiperazine with a Unique Spiro[furan-2,7'-pyrazino[1,2-b][1,2]oxazine] Skeleton, and a Related Analogue, Peniciadametizine B, from the Marine Sponge-Derived Fungus Penicillium adametzioides.青霉地嗪A，一种具有独特螺环[呋喃-2,7'-吡嗪并[1,2-b][1,2]恶嗪]骨架的二硫代二酮哌嗪，以及来自海洋海绵衍生真菌亚当齐奥德斯青霉的相关类似物青霉地嗪B。
Mar Drugs. 2015 Jun 5;13(6):3640-52. doi: 10.3390/md13063640.

引用本文的文献

1
Construction of an expression platform for fungal secondary metabolite biosynthesis in Penicillium crustosum.构建青霉属真菌次生代谢产物生物合成的表达平台。
Appl Microbiol Biotechnol. 2024 Jul 24;108(1):427. doi: 10.1007/s00253-024-13259-3.
2
Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.海洋真菌中的细胞毒性化合物：来源、结构和生物活性。
Mar Drugs. 2024 Jan 28;22(2):70. doi: 10.3390/md22020070.
3
Marine : A Treasure Trove of Antimicrobial Compounds.海洋：抗菌化合物的宝库。
Mar Drugs. 2023 Apr 28;21(5):277. doi: 10.3390/md21050277.
4
The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987-2020).海洋微生物含硫天然产物的有趣化学与生物学研究（1987 - 2020年）
Mar Life Sci Technol. 2021 May 19;3(4):488-518. doi: 10.1007/s42995-021-00101-2. eCollection 2021 Nov.
5
Chemical Investigation of Endophytic YSP3 Reveals New Antibacterial and Cytotoxic Agents.内生菌YSP3的化学研究揭示了新的抗菌和细胞毒性剂。
J Fungi (Basel). 2023 Jan 19;9(2):136. doi: 10.3390/jof9020136.
6
Biosynthesis of Xylariolide D in Implies a Chain Branching Reaction Catalyzed by a Highly Reducing Polyketide Synthase.木层孔菌素D在[具体内容缺失]中的生物合成意味着由一种高度还原型聚酮合酶催化的链分支反应。
J Fungi (Basel). 2022 May 9;8(5):493. doi: 10.3390/jof8050493.
7
Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review.新型海洋次生代谢产物值得开发为抗癌药物：综述。
Molecules. 2021 Sep 23;26(19):5769. doi: 10.3390/molecules26195769.
8
Structures and Biological Activities of Diketopiperazines from Marine Organisms: A Review.海洋生物中环二肽的结构和生物活性：综述。
Mar Drugs. 2021 Jul 21;19(8):403. doi: 10.3390/md19080403.
9
Diversity, Ecological Role and Biotechnological Potential of Antarctic Marine Fungi.南极海洋真菌的多样性、生态作用及生物技术潜力
J Fungi (Basel). 2021 May 17;7(5):391. doi: 10.3390/jof7050391.
10
Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.海洋沉积物来源真菌的代谢产物：生物活性研究的实际趋势。
Mar Drugs. 2021 Feb 4;19(2):88. doi: 10.3390/md19020088.