Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, GILIIP (GI, Liver and Innate Immunity Program), Graduate Program in Immunology, IMAGE (Investigations in Metabolism, Aging, Gender and Exercise), University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Mailstop #8620, Aurora, CO 80045, USA.
Division of GI, Trauma and Endocrine Surgery, Department of Surgery, Mucosal Inflammation Program, Graduate Program in Immunology, University of Colorado Denver, Anschutz Medical Campus, 12700 East 19th Avenue, Research Complex 2, Room 6460, Aurora, CO 80045, USA.
Clin Geriatr Med. 2017 Nov;33(4):459-471. doi: 10.1016/j.cger.2017.06.002. Epub 2017 Jul 14.
With the coming of the "silver tsunami," expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is timely and of immediate clinical need. The global population is increasing in age. By the year 2030, more than 20% of the population of the United States will be older than 65 years of age. This article focuses on how advanced age alters the immune systems and how this, in turn, modulates the ability of the aging lung to deal with infectious challenges from the outside world and from within the host.
随着“银色海啸”的到来，及时了解各种内在和外在因素如何影响老年人的免疫系统是非常及时和必要的。全球人口正在老龄化。到 2030 年，美国超过 20%的人口将超过 65 岁。本文重点介绍了年龄增长如何改变免疫系统，以及这反过来又如何调节衰老肺部应对来自外界和宿主内部的感染挑战的能力。
