Park Sooyeun, Lee Pilsoo, Ha Wi-Ho, Kim Han Sung, Park Byeong Ryong, Kim Jae Seok, Shim Sehwan, Park Sunhoo, Kim Young-Su, Kim Chan Hyeong, Jin Young-Woo
Laboratory of Health Physics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, 75 Nowon-gil, Nowon-gu 01812, Seoul, Republic of Korea.
Department of Nuclear Engineering, Hanyang University, 04763, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea.
J Radiat Res. 2017 Sep 1;58(5):755-760. doi: 10.1093/jrr/rrx036.
Quantification of pathological progression of radiation-induced injury is essential in development of treatment methods, and a proper animal model is necessary for relevant radiological and medical studies. A minipig is a current animal model selected because of its similarities to humans in anatomy and pathology. In the present study, a minipig physical phantom was developed using computed tomography (CT) data. For dosimetry purposes, the minipig physical phantom was constructed on a slice-by-slice basis, with an array of holes to accommodate dosimeters. The phantom is constituted of three major organs, i.e. bone, lung, and remaining soft tissue, and the organs are clearly distinguishable on each 20-mm-thick axial slice. The quality of the tissue-equivalent (TE) substitutes was analyzed in terms of the atomic compositions and Hounsfield units (HUs). The density (in g/cm3) and effective atomic number of TE substitutes for the bone, lung, and soft tissue are 1.4 and 7.9, 0.5 and 10.0, and 1.0 and 5.9, respectively. Although the TE substitutes have slightly different physical properties, we think the phantom is acceptable because the HU values of the TE substitutes lie in the HU range of real tissues.
辐射诱导损伤病理进展的量化对于治疗方法的开发至关重要，而合适的动物模型对于相关放射学和医学研究是必要的。小型猪是目前选择的动物模型，因为其在解剖学和病理学上与人类相似。在本研究中，利用计算机断层扫描（CT）数据开发了小型猪物理体模。出于剂量测定的目的，小型猪物理体模是逐片构建的，带有一系列用于容纳剂量计的孔。该体模由三个主要器官组成，即骨骼、肺和其余软组织，并且在每个20毫米厚的轴向切片上这些器官都清晰可辨。从原子组成和亨氏单位（HU）方面分析了组织等效（TE）替代物的质量。骨骼、肺和软组织的TE替代物的密度（以g/cm³为单位）和有效原子序数分别为1.4和7.9、0.5和10.0以及1.0和5.9。尽管TE替代物的物理性质略有不同，但我们认为该体模是可接受的，因为TE替代物的HU值处于真实组织的HU范围内。
