DNA结合的157Gd捕获中子后双链断裂的诱导
Induction of double-strand breaks following neutron capture by DNA-bound 157Gd.
作者信息
Martin R F, D'Cunha G, Pardee M, Allen B J
机构信息
Molecular Science Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
出版信息
Int J Radiat Biol. 1988 Aug;54(2):205-8. doi: 10.1080/09553008814551641.
PMID:2900277
Abstract
Irradiation of plasmid DNA/Gd3+ mixtures with thermal neutrons induces DNA double-strand breaks (dsb). However, the extent of breakage is markedly reduced by sequestering the Gd3+ from DNA by addition of EDTA. Since the 157Gd neutron capture event involves some internal conversion, we suggest that the DNA dsb induction results from Auger electron emission.
摘要
用热中子辐照质粒DNA/Gd3+混合物会诱导DNA双链断裂（dsb）。然而，通过添加EDTA将Gd3+与DNA隔离，断裂程度会显著降低。由于157Gd中子俘获事件涉及一些内转换，我们认为DNA dsb的诱导是由俄歇电子发射引起的。
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