人类10号染色体标记的初步遗传图谱。
A primary genetic map of markers of human chromosome 10.
作者信息
Lathrop M, Nakamura Y, Cartwright P, O'Connell P, Leppert M, Jones C, Tateishi H, Bragg T, Lalouel J M, White R
机构信息
Howard Hughes Medical Institute, University of Utah Medical Center, Salt Lake City 84132.
出版信息
Genomics. 1988 Feb;2(2):157-64. doi: 10.1016/0888-7543(88)90098-5.
We have constructed a primary genetic map for human chromosome 10 from 13 polymorphic marker systems defining 11 loci, using a new gene mapping algorithm implemented in the computer program GMS. The loci form a continuous genetic map that spans approximately 116 cM in males and 170 cM in females. These loci provide regularly spaced anchor points for linkage studies, except for one interval that is 28 cM in males and 64 cM in females.
我们使用计算机程序GMS中实施的一种新的基因定位算法，从定义11个基因座的13个多态性标记系统构建了人类10号染色体的初级遗传图谱。这些基因座形成了一个连续的遗传图谱，在男性中跨度约为116厘摩，在女性中跨度约为170厘摩。这些基因座为连锁研究提供了间隔均匀的锚定点，但有一个区间在男性中为28厘摩，在女性中为64厘摩。
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