Wang Xianwang, Peng Xiaochun, Zhang Xueqing, Xu Hanyi, Lu Chengbiao, Liu Lian, Song Jiaxing, Zhang Yingjie
The Second Clinical Medical School of Yangtze University & Jingzhou Central Hospital, Jingzhou, China.
Key Laboratory of Oncology, Center for Molecular Medicine, School of Medicine, Yangtze University, Jingzhou, China.
Cell Physiol Biochem. 2017;43(4):1413-1424. doi: 10.1159/000481873. Epub 2017 Oct 11.
Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis. A number of studies have found that CIB1 is ubiquitously expressed and is related to various human diseases, such as cancer, Alzheimer's disease (AD), cardiac hypertrophy and male infertility. The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting with numerous interacting partners. As a calcium binding protein, the roles of CIB1 in calcium signaling by binding calcium or modulating some key modulators, such as calcineurin, integrin, inositol 1,4,5-trisphosphate receptor (IP3R) and taste 1 receptor member 2 (TAS1R2). The tumor promoting mechanisms of CIB1 have been described in different aspects, including promoting tumor cell cycle and proliferation, inhibiting tumor cell apoptosis, and mediating tumor cell migration and angiogenesis. In addition, multiple functions of CIB1, such as neural development, taste or gustation functions, and virus infection are also elucidated. These recent advances have significantly expanded our understanding of the knowledge of CIB1 and highlighted the potential mechanisms of CIB1 in tumor progression.
钙与整合素结合蛋白1（CIB1）是一种EF手型钙结合蛋白，参与许多细胞过程，包括钙信号传导、细胞存活与增殖、细胞迁移、细胞黏附及凋亡。多项研究发现，CIB1广泛表达，且与多种人类疾病相关，如癌症、阿尔茨海默病（AD）、心肌肥大及男性不育。尽管CIB1的多种功能通过与众多相互作用蛋白相互作用来调节，但其在人类疾病中的机制仍不清楚。作为一种钙结合蛋白，CIB1通过结合钙或调节一些关键调节因子，如钙调神经磷酸酶、整合素、肌醇1,4,5-三磷酸受体（IP3R）和味觉1受体成员2（TAS1R2），在钙信号传导中发挥作用。CIB1的肿瘤促进机制已从不同方面进行了描述，包括促进肿瘤细胞周期和增殖、抑制肿瘤细胞凋亡以及介导肿瘤细胞迁移和血管生成。此外，CIB1的多种功能，如神经发育、味觉或味觉功能以及病毒感染也得到了阐明。这些最新进展显著扩展了我们对CIB1知识的理解，并突出了CIB1在肿瘤进展中的潜在机制。
