乌舒鲁病毒，奥地利和匈牙利，2010-2016 年。
Usutu virus, Austria and Hungary, 2010-2016.
机构信息
Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine, Veterinaerplatz 1, 1210 Vienna, Austria.
Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Budapest, Hungária krt. 23-25, 1143 Budapest, Hungary.
出版信息
Emerg Microbes Infect. 2017 Oct 11;6(10):e85. doi: 10.1038/emi.2017.72.
Usutu virus (USUV, Flaviviridae) was first reported in Europe in Austria in 2001, where it caused wild bird (mainly blackbird) mortality until 2005. Since 2006 no further USUV cases were diagnosed in the country. However, the virus emerged in other European countries (Hungary, Italy, Switzerland, Spain, Germany and the Czech Republic) between 2005 and 2011. In 2016, widespread USUV-associated wild bird mortality was observed in Germany, France, Belgium and the Netherlands. In this study, we report the results of passive monitoring for USUV in Austria and Hungary between 2010 and 2016. In Hungary, USUV caused sporadic cases of wild bird mortality between 2010 and 2015 (altogether 18 diagnosed cases), whereas in summer and autumn 2016 the number of cases considerably increased to 12 (ten blackbirds, one Eurasian jay and one starling). In Austria, USUV was identified in two blackbirds in 2016. Phylogenetic analyses of coding-complete genomes and partial regions of the NS5 protein gene revealed that USUVs from Hungary between 2010 and 2015 are closely related to the virus that emerged in Austria in 2001 and in Hungary in 2005, while one Hungarian sequence from 2015 and all sequences from Hungary and Austria from 2016 clustered together with USUV sequences reported from Italy between 2009 and 2010. The results of the study indicate continuous USUV circulation in the region and exchange of USUV strains between Italy, Austria and Hungary.Emerging Microbes &Infections (2017) 6, e85; doi:10.1038/emi.2017.72; published online 11 October 2017.
乌苏图病毒（USUV，黄病毒科）于 2001 年在奥地利首次报告于欧洲，在 2005 年之前导致野生鸟类（主要是乌鸫）死亡。自 2006 年以来，该国未再诊断出 USUV 病例。然而，该病毒于 2005 年至 2011 年期间出现在其他欧洲国家（匈牙利、意大利、瑞士、西班牙、德国和捷克共和国）。2016 年，德国、法国、比利时和荷兰广泛观察到与 USUV 相关的野生鸟类死亡。在这项研究中，我们报告了 2010 年至 2016 年期间在奥地利和匈牙利进行的被动监测 USUV 的结果。在匈牙利，2010 年至 2015 年期间，USUV 导致零星的野生鸟类死亡病例（总共 18 例确诊病例），而 2016 年夏季和秋季，病例数量大幅增加至 12 例（10 只乌鸫、1 只松鸦和 1 只八哥）。在奥地利，2016 年鉴定出两只黑鸟感染了 USUV。编码完整基因组和 NS5 蛋白基因部分区域的系统发育分析表明，2010 年至 2015 年期间匈牙利的 USUV 与 2001 年在奥地利和 2005 年在匈牙利出现的病毒密切相关，而 2015 年的一个匈牙利序列和 2016 年来自匈牙利和奥地利的所有序列与 2009 年至 2010 年期间报告的来自意大利的 USUV 序列聚集在一起。该研究的结果表明，该地区持续存在 USUV 循环，并在意大利、奥地利和匈牙利之间交换 USUV 株。新兴微生物和感染（2017 年）6，e85；doi:10.1038/emi.2017.72；在线出版于 2017 年 10 月 11 日。
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