Department of Plastic Surgery, Hangzhou First People's Hospital, Nanjing Medical University, No. 261 Huansha Road, Hangzhou, 310006, China.
Eur J Med Res. 2017 Oct 11;22(1):39. doi: 10.1186/s40001-017-0278-5.
Platelet-rich plasma (PRP) is an autologous concentration of human platelets in plasma. In this paper, we aimed to investigate the effect of PRP on hair growth.
Platelet-rich plasma and platelet-poor plasma were prepared by sterile centrifugation and injected into shaved dorsal skin of mice (n = 10). Saline injection was used in the control group. The length of randomly plucked hairs was measured at 8, 13, 18 days after PRP injection. Histological examination was preformed to observe the histologic changes of skins. The immunohistochemistry analysis of CD31 was performed to detect the changes of hair length and formation of new vessels.
At 13 and 18 days after the last injection, the hair length of mice in PRP group (4.24 ± 0.60 and 8.29 ± 0.48 mm, respectively) was significantly longer compared with the control group (3.70 ± 0.52 and 7.21 ± 0.64 mm, p < 0.05). No significant difference in the hair length was found between the PPP group and the control (p > 0.05). In addition, the number of CD31-positive vessel in the PRP group (9.90 ± 0.60) was more than that in the control group (8.60 ± 2.34, p < 0.05).
Platelet-rich plasma might promote hair length growth and increase the number of hair follicles by inducing angiogenesis.
富血小板血浆（PRP）是一种自体人血小板在血浆中的浓缩物。本文旨在研究 PRP 对毛发生长的影响。
通过无菌离心制备富血小板血浆和血小板少血浆，并将其注入剃光的小鼠背部皮肤（n=10）。对照组注射生理盐水。在 PRP 注射后 8、13、18 天随机拔出毛发并测量长度。进行组织学检查观察皮肤的组织学变化。进行 CD31 的免疫组化分析，以检测毛发生长和新血管形成的变化。
末次注射后 13 天和 18 天，PRP 组小鼠的毛发长度（4.24±0.60 和 8.29±0.48 mm）明显长于对照组（3.70±0.52 和 7.21±0.64 mm，p<0.05）。PPP 组与对照组之间的毛发长度无显著差异（p>0.05）。此外，PRP 组的 CD31 阳性血管数（9.90±0.60）多于对照组（8.60±2.34，p<0.05）。
PRP 可能通过诱导血管生成促进毛发生长和增加毛囊数量。
