Lasso Fabricio Andres, Zamora Bastidas Tomas Omar, Potosí García Jorge Andrés, Díaz Idrobo Bairon
Facultad de Medicina, Universidad del Cauca. Cauca, Colombia.
Medicina Interna. Facultad de Medicina. Universidad del Cauca. Cauca, Colombia.
Colomb Med (Cali). 2017 Jun 30;48(2):94-97.
Cryptococcosis is an opportunistic fungal infection whose etiology is complex which affects immunocompromised patients mainly. Meningeal infection is one of the most common presentations, but cerebellar affection is rare.
Male patient with 65 old years, from an area of subtropical climate with chronic exposure to poultry, without pathological antecedents, who presented clinical picture consistent with headache, fever, seizures and altered mental status.
Initially without menigeal signs or intracranial hypertension and normal neurological examination. Later, the patient developed ataxia, dysdiadochokinesia and limb loss. By lumbar punction and image of nuclear magnetic resonance (NMR) cerebellitis cryptococcal was diagnosticated.
Antifungal therapy with amphotericin B and fluconazole was performed, however the patient died.
The cryptococcosis has different presentations, it´s a disease whose incidence has been increasing since the advent of the HIV / AIDS pandemy, however the commitment of the encephalic parenchyma and in particular the cerebellum is considered rare. In this way we are facing the first case of cryptococcal cerebellitis in our midst.
隐球菌病是一种机会性真菌感染，其病因复杂，主要影响免疫功能低下的患者。脑膜感染是最常见的表现之一，但小脑受累较为罕见。
一名65岁男性患者，来自亚热带气候地区，长期接触家禽，无既往病史，出现头痛、发热、癫痫发作和精神状态改变等临床表现。
最初无脑膜刺激征或颅内高压，神经系统检查正常。后来，患者出现共济失调、轮替运动障碍和肢体无力。通过腰椎穿刺和核磁共振成像诊断为隐球菌性小脑炎。
采用两性霉素B和氟康唑进行抗真菌治疗，但患者死亡。
隐球菌病有不同的表现形式，自艾滋病大流行以来，其发病率一直在上升，然而脑实质尤其是小脑受累被认为较为罕见。因此，我们遇到了首例隐球菌性小脑炎病例。
