Guo Chenjia, Wu Ping, Xue Jinghua, Li Hanxiang, Wei Xiaoyi
a Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany , Chinese Academy of Sciences , Guangzhou , People's Republic of China.
Nat Prod Res. 2018 Jul;32(13):1525-1531. doi: 10.1080/14786419.2017.1385013. Epub 2017 Oct 12.
Two new γ-pyrones, xylaropyrones B (1) and C (2), together with three known compounds, xylaropyrone (3), annularin A (4) and annularin C (5), were isolated from solid cultures of the endophytic fungus Xylaria sp. SC1440. The structures of these compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configurations of 1 and 2 were assigned on the basis of J-based configurational analysis, and the absolute configurations were established by experimental and TDDFT calculated ECD spectra. The isolated compounds were evaluated for cytotoxic and tyrosinase inhibitory activity.
从内生真菌炭角菌属Xylaria sp. SC1440的固体培养物中分离得到两个新的γ-吡喃酮，即木层孔菌素B（1）和C（2），以及三个已知化合物，木层孔菌素（3）、环孢菌素A（4）和环孢菌素C（5）。这些化合物的结构主要通过对其核磁共振光谱数据的分析来确定。1和2的相对构型基于基于J的构型分析进行指定，绝对构型通过实验和TDDFT计算的ECD光谱确定。对分离得到的化合物进行了细胞毒性和酪氨酸酶抑制活性评估。
