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来自马铃薯内生真菌E10的六种前所未有的细胞松弛素衍生物及其细胞毒性。

Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus E10 and Their Cytotoxicity.

作者信息

Zhang Xian, Fan Yinzhong, Ye Ke, Pan Xiaoyan, Ma Xujun, Ai Honglian, Shi Baobao, Liu Jikai

机构信息

School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.

出版信息

Pharmaceuticals (Basel). 2023 Jan 28;16(2):193. doi: 10.3390/ph16020193.

DOI:10.3390/ph16020193
PMID:37259342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9964435/
Abstract

Six previously undescribed cytochalasins, Curtachalasins X1-X6 (-), together with six known compounds (-) were isolated from the endophytic fungus E10 harbored in the plant . The structures were elucidated by the interpretation of HRESIMS, UV, and NMR data. The absolute configurations of Curtachalasins X1-X6 were determined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. In bioassays, Curtachalasin X1 () and X5 () showed cytotoxic activity against the MCF-7 cell line with IC values of 2.03 μM and 0.85 μM, respectively.

摘要

从该植物内生真菌E10中分离出6种之前未描述过的细胞松弛素，即短柄细胞松弛素X1 - X6（-），以及6种已知化合物（-）。通过对高分辨电喷雾电离质谱（HRESIMS）、紫外光谱（UV）和核磁共振谱（NMR）数据的解析确定了其结构。通过比较短柄细胞松弛素X1 - X6的实验和计算电子圆二色光谱（ECD）确定了它们的绝对构型。在生物活性测试中，短柄细胞松弛素X1（）和X5（）对MCF - 7细胞系显示出细胞毒性活性，其半数抑制浓度（IC）值分别为2.03 μM和0.85 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/551450b7a483/pharmaceuticals-16-00193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/5456e19ca291/pharmaceuticals-16-00193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/bd8446a2699e/pharmaceuticals-16-00193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/f5b661e4ed68/pharmaceuticals-16-00193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/551450b7a483/pharmaceuticals-16-00193-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/5456e19ca291/pharmaceuticals-16-00193-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/bd8446a2699e/pharmaceuticals-16-00193-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/f5b661e4ed68/pharmaceuticals-16-00193-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/9964435/551450b7a483/pharmaceuticals-16-00193-g004.jpg

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