从一株源自红树林的真菌埃氏炭角菌HJ001中分离出一种新的细胞松弛素代谢产物。
One new cytochalasin metabolite isolated from a mangrove-derived fungus Daldinia eschscholtzii HJ001.
作者信息
Yang Lu-Jia, Liao Hai-Xia, Bai Meng, Huang Guo-Lei, Luo You-Ping, Niu Yan-Yan, Zheng Cai-Juan, Wang Chang-Yun
机构信息
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering , Hainan Normal University , Haikou , China.
b Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, The Ministry of Education of China , Ocean University of China , Qingdao , China.
出版信息
Nat Prod Res. 2018 Jan;32(2):208-213. doi: 10.1080/14786419.2017.1346641. Epub 2017 Jun 28.
One new cytochalasin metabolite [11]-cytochalasa-5(6),13-diene-1,21-dione-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*) (1), together with three known compounds (2-4) were obtained from the EtOAc extract of the endophytic fungus Daldinia eschscholtzii HJ001 isolated from the mangrove Brguiera sexangula var. rhynchopetala collected in the South China Sea. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. Compounds 1 and 2 were evaluated for their antibacterial and cytotoxic activities.
从采自中国南海的红树植物木榄变种尖瓣海莲的内生真菌埃氏炭角菌HJ001的乙酸乙酯提取物中，得到了一种新的细胞松弛素代谢产物[11]-细胞松弛素-5(6),13-二烯-1,21-二酮-7,18-二羟基-16,18-二甲基-10-苯基-(7S*,13E,16S*,18R*) (1)，以及三种已知化合物(2 - 4)。通过对综合光谱数据的详细分析确定了它们的结构。对化合物1和2进行了抗菌和细胞毒性活性评价。
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