Graduate Institute of Pharmacognosy, Taipei, Taiwan.
The Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, Taipei Medical University, Taipei, Taiwan.
J Food Drug Anal. 2019 Jan;27(1):111-117. doi: 10.1016/j.jfda.2018.05.007. Epub 2018 Jun 18.
Seven new isoprenyl phenolic ethers, namely fimbriethers A‒G (1‒7), were isolated from the fermented broth of the termite nest-derived medicinal fungus Xylaria fimbriata YMJ491. Their structures were determined by spectroscopic data analysis and compared with those reported. The effects of all the isolates at a concentration of 100 μM on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells were evaluated, and all of them exhibited NO production inhibitory activity with E values ranging from 4.6 ± 2.0% to 49.7 ± 0.5% without significant cytotoxicity. In addition, these seven compounds did not alter phenylephrine-induced vasocontraction in isolated intact thoracic aortic rings from C57BL/6J mouse, indicating 1‒7 were not involved in the regulation of endothelial NOS-mediated NO production.
从白蚁巢来源的药用真菌黄韧革菌 YMJ491 的发酵液中分离得到了 7 个新的异戊烯基酚醚类化合物，分别命名为 fimbriethers A-G（1-7）。通过光谱数据分析确定了它们的结构，并与已报道的结构进行了比较。在 100 μM 浓度下，所有分离物对脂多糖（LPS）诱导的鼠巨噬细胞 RAW 264.7 细胞中一氧化氮（NO）产生的抑制作用进行了评估，结果显示它们均具有 NO 产生抑制活性，半数有效值（E 值）范围为 4.6±2.0%至 49.7±0.5%，且无明显细胞毒性。此外，这 7 种化合物在分离的 C57BL/6J 小鼠完整胸主动脉环中对苯肾上腺素诱导的血管收缩没有影响，表明 1-7 不参与内皮型一氧化氮合酶（eNOS）介导的 NO 产生的调节。
