Vallianou Natalia G, Georgousopoulou Ekavi, Evangelopoulos Angelos A, Bountziouka Vassiliki, Bonou Maria S, Vogiatzakis Evangelos D, Avgerinos Petros C, Barbetseas John, Panagiotakos Demosthenes B
Evangelismos General Hospital, Athens, Greece.
Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece.
Cent Eur J Public Health. 2017 Sep;25(3):240-244. doi: 10.21101/cejph.a4786.
The aim of the present study was to examine serum cystatin C levels in association with the Mediterranean diet in a healthy Greek population.
Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46±16 years, 40% of males), who underwent an annual health check. Demographic, anthropometric and lifestyle characteristics were recorded, while adherence to the Mediterranean diet was evaluated through the MedDietScore (0-55).
The mean level of serum cystatin C was 0.84 mg/L, while men had increased serum cystatin C levels compared to women (0.86 mg/L vs. 0.83 mg/L, respectively, 0.017). After adjusting for age, gender, body mass index, smoking status, hypertension, diabetes, hypercholesterolemia, estimated glomerular filtration rate (eGFR), albumin and ferritin levels, each unit increase in MedDietScore led to 0.002 mg/dL drop off in cystatin C serum levels.
We have demonstrated an inverse relationship between the MedDietScore and serum cystatin C levels. Our finding that increases in MedDietScore are associated with decreases in serum cystatin C levels could imply that adherence to the Mediterranean diet may reduce the cardiovascular risk, as assessed by cystatin C, a prognostic marker of the cardiometabolic risk. This notion could have a great impact on public health.
本研究旨在调查健康希腊人群中血清胱抑素C水平与地中海饮食之间的关系。
对总共490名成年人（46±16岁，男性占40%）进行年度健康检查时，检测了胱抑素C以及基本临床化学指标。记录了人口统计学、人体测量学和生活方式特征，同时通过地中海饮食评分（0 - 55分）评估对地中海饮食的依从性。
血清胱抑素C的平均水平为0.84mg/L，男性的血清胱抑素C水平高于女性（分别为0.86mg/L和0.83mg/L，P = 0.017）。在调整年龄、性别、体重指数、吸烟状况、高血压、糖尿病、高胆固醇血症、估计肾小球滤过率（eGFR）、白蛋白和铁蛋白水平后，地中海饮食评分每增加一个单位，胱抑素C血清水平下降0.002mg/dL。
我们证明了地中海饮食评分与血清胱抑素C水平之间存在负相关关系。我们的研究结果表明，地中海饮食评分的增加与血清胱抑素C水平的降低相关，这可能意味着坚持地中海饮食可能会降低心血管风险，胱抑素C是心血管代谢风险的一个预后指标，可用于评估心血管风险。这一观点可能对公共卫生产生重大影响。
