Department of Nutritional Sciences, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI48109-2029, USA.
RTI International, Raleigh, NC, USA.
Public Health Nutr. 2021 Oct;24(14):4603-4613. doi: 10.1017/S1368980020005236. Epub 2020 Dec 23.
The association between organic food consumption and biomarkers of inflammation, C-reactive protein (CRP) and cystatin C (CysC) was explored in this cross-sectional analysis of older adults.
Dietary data and organic food consumption was collected in 2013 from a FFQ. Alternative Mediterranean diet score (A-MedDiet) was calculated as a measure of healthy eating. Biomarkers CRP and CysC were collected in serum or plasma in 2016. We used linear regression models to assess the associations between organic food consumption and CRP and CysC.
This cross-sectional analysis uses data from the nationally representative, longitudinal panel study of Americans over 50, the Health and Retirement Study.
The mean age of the analytic sample (n 3815) was 64·3 (se 0·3) years with 54·4 % being female.
Log CRP and log CysC were inversely associated with consuming organic food after adjusting for potential confounders (CRP: β = -0·096, 95 % CI 0·159, -0·033; CysC: β = -0·033, 95 % CI -0·051, -0·015). Log CRP maintained statistical significance (β = -0·080; 95 % CI -0·144, -0·016) after additional adjustments for the A-MedDiet, while log CysC lost statistical significance (β = -0·019; 95 % CI -0·039, 0·000). The association between organic food consumption and log CRP was driven primarily by milk, fruit, vegetables and cereals, while log CysC was primarily driven by milk, eggs and meat after adjustments for A-MedDiet.
These findings support the hypothesis that organic food consumption is inversely associated with biomarkers of inflammation CRP and CysC, although residual confounding by healthy eating and socioeconomic status cannot be ruled out.
本横断面分析探讨了老年人中有机食品消费与炎症标志物 C 反应蛋白（CRP）和胱抑素 C（CysC）之间的关系。
2013 年采用 FFQ 收集膳食数据和有机食品消费情况。替代地中海饮食评分（A-MedDiet）作为健康饮食的衡量标准。2016 年采集血清或血浆中的 CRP 和 CysC 生物标志物。我们使用线性回归模型评估有机食品消费与 CRP 和 CysC 之间的关系。
本横断面分析使用了来自美国 50 岁以上人群的全国代表性纵向面板研究——健康与退休研究的数据。
分析样本的平均年龄（n=3815）为 64.3（se=0.3）岁，其中 54.4%为女性。
在调整潜在混杂因素后，食用有机食品与 CRP 和 CysC 的对数呈负相关（CRP：β=-0.096，95%CI 0.159，-0.033；CysC：β=-0.033，95%CI-0.051，-0.015）。在进一步调整 A-MedDiet 后，CRP 的对数仍具有统计学意义（β=-0.080；95%CI-0.144，-0.016），而 CysC 的对数失去统计学意义（β=-0.019；95%CI-0.039，0.000）。食用有机食品与 CRP 对数之间的关系主要受牛奶、水果、蔬菜和谷物驱动，而在调整 A-MedDiet 后，CysC 对数主要受牛奶、鸡蛋和肉类驱动。
这些发现支持了有机食品消费与 CRP 和 CysC 等炎症标志物呈负相关的假设，尽管健康饮食和社会经济地位的残余混杂因素无法排除。
