University of California San Diego-San Diego State University Joint Doctoral Program in Public Health, La Jolla, California.
Division of Child Development and Community Health, Department of Pediatrics, University of California, San Diego, California.
Prev Chronic Dis. 2017 Oct 12;14:E93. doi: 10.5888/pcd14.170132.
Obesity and metabolic syndrome (MetS) indicators have increased globally among the pediatric population. MetS indicators in the young elevate their risk of cardiovascular disease and metabolic disorders later in life. This study examined early onset obesity as a risk factor for MetS risk in adolescence.
A cohort of Chilean participants (N = 673) followed from infancy was assessed at age 5 years and in adolescence (mean age, 16.8 y). Adiposity was measured at both time points; blood pressure and fasting blood samples were assessed in adolescence only. Early onset obesity was defined as a World Health Organization z score of 2 standard deviations (SDs) or more for body mass index (BMI) at age 5 years. We used linear regression to examine the association between early onset obesity and adolescent MetS risk z score, adjusting for covariates.
Eighteen percent of participants had early onset obesity, and 50% of these remained obese in adolescence. Mean MetS risk z score in adolescence was significantly higher among those with early onset obesity than among those without (1.0; SD, 0.8 vs 0.2; SD, 0.8 [P < .001]). In the multivariable model, early onset obesity independently contributed to a higher MetS risk score in adolescence (β = 0.27, P < .001), controlling for obesity status at adolescence and sex, and explained 39% of the variance in MetS risk.
Early onset obesity as young as age 5 years relates to higher MetS risk.
肥胖和代谢综合征（MetS）指标在全球儿科人群中呈上升趋势。年轻人的 MetS 指标会增加其日后患心血管疾病和代谢紊乱的风险。本研究探讨了早期肥胖作为青少年患 MetS 风险的一个危险因素。
本研究对智利参与者（N=673）进行了队列研究，从婴儿期开始随访，在 5 岁和青少年时期（平均年龄 16.8 岁）进行评估。在两个时间点测量肥胖程度；仅在青少年时期评估血压和空腹血样。早期肥胖定义为 5 岁时体重指数（BMI）的世界卫生组织 z 分数达到 2 个标准差（SD）或更高。我们使用线性回归来检验早期肥胖与青少年 MetS 风险 z 分数之间的关系，调整了协变量。
18%的参与者有早期肥胖，其中 50%在青少年时期仍然肥胖。与无早期肥胖者相比，有早期肥胖者青少年时期的 MetS 风险 z 评分明显更高（1.0；SD，0.8 与 0.2；SD，0.8[P<0.001]）。在多变量模型中，早期肥胖与青少年时期更高的 MetS 风险评分独立相关（β=0.27，P<0.001），控制了青少年时期的肥胖状况和性别，解释了 MetS 风险的 39%。
早在 5 岁时出现的早期肥胖与更高的 MetS 风险相关。
