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产肠毒素和细胞毒性肠炎沙门氏菌及鼠伤寒沙门氏菌的细胞表面特性:关于血凝、细胞表面疏水性、对人肠道细胞的黏附及纤连蛋白结合的研究

Cell-surface properties of enterotoxigenic and cytotoxic Salmonella enteritidis and Salmonella typhimurium: studies on hemagglutination, cell-surface hydrophobicity, attachment to human intestinal cells and fibronectin-binding.

作者信息

Baloda S B, Faris A, Krovacek K

机构信息

Department of Veterinary Microbiology, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.

出版信息

Microbiol Immunol. 1988;32(5):447-59. doi: 10.1111/j.1348-0421.1988.tb01405.x.

DOI:10.1111/j.1348-0421.1988.tb01405.x
PMID:2902507
Abstract

Thirteen Salmonella enteritidis and S. typhimurium strains with smooth or rough colony morphology were investigated for their surface properties based on hemagglutination (HA), hydrophobicity, and fibronectin-binding profiles. The strains showed 5 different patterns of HA which was mannose-sensitive. The rough strains possessed comparatively greater number of fimbriae than the corresponding smooth strains and also attached to human intestinal cells in greater numbers. The Salmonella strains used in this study interacted with fibronectin and its 29-kDa N-terminal fragment to varied extents. These properties may be helpful in broadening the prospective interaction capabilities of Salmonella organisms with the host surfaces.

摘要

对13株具有光滑或粗糙菌落形态的肠炎沙门氏菌和鼠伤寒沙门氏菌菌株,基于血凝(HA)、疏水性和纤连蛋白结合谱研究了它们的表面特性。这些菌株显示出5种对甘露糖敏感的不同HA模式。粗糙菌株比相应的光滑菌株拥有相对更多数量的菌毛,并且也能以更多数量附着于人类肠道细胞。本研究中使用的沙门氏菌菌株与纤连蛋白及其29 kDa的N端片段有不同程度的相互作用。这些特性可能有助于拓宽沙门氏菌与宿主表面的潜在相互作用能力。

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The ability of Salmonella to enter mammalian cells is affected by bacterial growth state.沙门氏菌进入哺乳动物细胞的能力受细菌生长状态的影响。
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