Abraham Preetha Anna, Attipoe Selasi, Kazman Josh B, Zeno Stacey Anne, Poth Merrily, Deuster Patricia Anne
Department of Military and Emergency Medicine (MEM) Uniformed Services University of Health Sciences (USUHS) 4301 Jones Bridge Rd, Bethesda, MD 20814 (PA, SA, JK, SZ, PD).
Afr Health Sci. 2017 Mar;17(1):99-107. doi: 10.4314/ahs.v17i1.13.
Obesity is a modifiable risk factor for hypertension and T2D. Objective(s): We examined relations between fasting plasma adiponectin (ADIP), C-reactive protein (CRP) concentrations and markers of T2D in African Americans (AA).
Fasting plasma ADIP, CRP, Insulin (IN), HOMA-IR, lipid profiles, body fat percent (%BF), waist circumference (WC), body mass index (BMI) and blood pressure measures were determined in AA women (W: n=77) and men (M: n=34). Participants were classified into: 1) Normal fasting glucose (FG) and Normal %BF; 2) Normal FG and High %BF; and 3) High FG.
Compared to men, women had significantly higher mean ADIP (W: 31.4±2.9 vs. M: 18.0±4.4 ng/L), CRP (W: 3.2±0.3 vs. M: 2.0±0.5 mg/L), %BF (W: 41.2±0.9 vs. M: 27.2±1.3), and BMI (W: 32.3±0.7 vs. M: 29.2±1.1 kg/m2). Women with normal FG and %BF had significantly higher ADIP (64.0±6.0) and lower CRP (1.3±0.6) concentrations than normal FG/ high %BF (ADIP: 37.0±5.0 and CRP: 3.1 ±0.5) and high FG (ADIP: 15.1±4.1 and CRP: 4.0 ± 0.5) groups. Women with high ADIP to CRP ratio had favorable metabolic and anthropometric profiles.
Low ADIP and high CRP are associated with excessive %BF and FG in AA women. ADIP/CRP, may be useful for detecting metabolic dysregulation.
肥胖是高血压和2型糖尿病的一个可改变的风险因素。目的：我们研究了非裔美国人（AA）空腹血浆脂联素（ADIP）、C反应蛋白（CRP）浓度与2型糖尿病标志物之间的关系。
测定了AA女性（W：n = 77）和男性（M：n = 34）的空腹血浆ADIP、CRP、胰岛素（IN）、稳态模型评估胰岛素抵抗（HOMA-IR）、血脂谱、体脂百分比（%BF）、腰围（WC）、体重指数（BMI）和血压指标。参与者被分为：1）空腹血糖（FG）正常且%BF正常；2）空腹血糖正常但%BF高；3）空腹血糖高。
与男性相比，女性的平均ADIP（W：31.4±2.9 vs. M：18.0±4.4 ng/L）、CRP（W：3.2±0.3 vs. M：2.0±0.5 mg/L）、%BF（W：41.2±0.9 vs. M：27.2±1.3）和BMI（W：32.3±0.7 vs. M：29.2±1.1 kg/m2）显著更高。空腹血糖和%BF正常的女性的ADIP浓度（64.0±6.0）显著高于空腹血糖正常/%BF高（ADIP：37.0±5.0和CRP：3.1±0.5）和空腹血糖高（ADIP：15.1±4.1和CRP：4.0±0.5）组，而CRP浓度（1.3±0.6）则更低。ADIP与CRP比值高的女性具有良好的代谢和人体测量学特征。
低ADIP和高CRP与AA女性的%BF过高和空腹血糖升高有关。ADIP/CRP可能有助于检测代谢失调。
