Rondanelli Mariangela, Gasparri Clara, Pirola Martina, Barrile Gaetan Claude, Moroni Alessia, Sajoux Ignacio, Perna Simone
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona ''Istituto Santa Margherita'', University of Pavia, 27100 Pavia, Italy.
Nutrients. 2024 Nov 22;16(23):4002. doi: 10.3390/nu16234002.
The ketogenic diet has emerged as a potential treatment strategy for reducing inflammation. The purpose of this meta-analysis and systematic review is to look into how a ketogenic diet affects inflammatory biomarkers in persons who are overweight or obese. . We conducted an extensive search of Web of Science, PubMed, Scopus, and Google Scholar to find pertinent studies reporting changes in inflammatory biomarkers such as C-reactive protein (CRP), the erythrocyte sedimentation rate, and cytokines after a ketogenic diet. Seven randomized controlled trials involving 218 overweight or obese individuals who followed a ketogenic or control diet over 8 weeks to 2 years were included in the review, and five of those were considered for the meta-analysis. The primary outcomes were CRP and IL-6 levels. The results reported significant decreases after treatment for CRP (mean of -0.62 mg/dL (95% CI: -0.84, -0,40), and a slight, but not statistically significant, reduction in IL-6 (mean of -1.31 pg/mL (95% CI: -2.86, 0.25). . The ketogenic diet could contribute to modulating inflammation in obese and overweight subjects.
生酮饮食已成为一种潜在的减轻炎症的治疗策略。本荟萃分析和系统评价的目的是研究生酮饮食如何影响超重或肥胖人群的炎症生物标志物。我们对科学网、PubMed、Scopus和谷歌学术进行了广泛检索，以查找相关研究，这些研究报告了生酮饮食后炎症生物标志物如C反应蛋白（CRP）、红细胞沉降率和细胞因子的变化。该评价纳入了7项随机对照试验，涉及218名超重或肥胖个体，他们在8周至2年的时间里遵循生酮饮食或对照饮食，其中5项试验被纳入荟萃分析。主要结局指标为CRP和IL-6水平。结果报告显示，治疗后CRP显著降低（平均降低-0.62mg/dL（95%CI：-0.84，-0.40）），IL-6有轻微但无统计学意义的降低（平均降低-1.31pg/mL（95%CI：-2.86，0.25））。生酮饮食可能有助于调节肥胖和超重受试者的炎症。
