Yang Aram, Kang Ben, Choe Jae Young, Kim Hye Seung, Kim Kyunga, Choe Yon Ho
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.
Pediatr Gastroenterol Hepatol Nutr. 2017 Sep;20(3):160-166. doi: 10.5223/pghn.2017.20.3.160. Epub 2017 Sep 26.
The prevalence of reflux esophagitis (RE) has increased recently in Korea. Little is known concerning the prevalence and characteristics of RE in pediatric patients. This study investigated the prevalence and influence of risk factors in endoscopically proven RE in Korea in pediatric patients over a period of 14 years.
A retrospective chart review of all patients between the ages of 1 month and 20 years who underwent esophagogastroduodenoscopy at Samsung Medical Center between 2001 and 2014 was carried out. Univariate and multivariate analyses were conducted to identify independent risk factors for RE.
The prevalence rate of endoscopically proven RE in this study was 28.7% (978/3,413). The prevalence of RE increased from 11.8% from 2001 to 2007 to 37.7% from 2008 to 2014. Multivariate logistic regression analysis revealed that residency in the Greater Gangnam area (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.02-1.44) and age (OR, 1.13; 95% CI, 1.11-1.15) were significant predictive factors for the presence of RE.
The prevalence rate of endoscopically proven pediatric RE has increased over the past 14 years. Residency and older age are more important independent risk factors for pediatric RE in Korea.
反流性食管炎（RE）在韩国的患病率近来有所上升。关于小儿患者中RE的患病率及特征，人们知之甚少。本研究调查了14年间韩国经内镜证实的小儿RE患者的患病率及其危险因素的影响。
对2001年至2014年期间在三星医疗中心接受食管胃十二指肠镜检查的年龄在1个月至20岁之间的所有患者进行回顾性病历审查。进行单因素和多因素分析以确定RE的独立危险因素。
本研究中经内镜证实的RE患病率为28.7%（978/3413）。RE的患病率从2001年至2007年的11.8%上升至2008年至2014年的37.7%。多因素逻辑回归分析显示，居住在江南大区（比值比[OR]，1.21；95%置信区间[CI]，1.02 - 1.44）和年龄（OR，1.13；95%CI，1.11 - 1.15）是RE存在的显著预测因素。
在过去14年中，经内镜证实的小儿RE患病率有所上升。居住地区和年龄较大是韩国小儿RE更重要的独立危险因素。
