Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Flowers Building, 1st floor South Kensington Campus, Imperial College London, London SW7 2AZ, UK.
Department of Environmental Protection, Estación Experimental del Zaidín-Consejo Superior de Investigaciones Científicas, 18008 Granada, Spain.
Environ Microbiol. 2018 Jan;20(1):1-15. doi: 10.1111/1462-2920.13956. Epub 2017 Nov 10.
The type VI secretion system (T6SS) is a bacterial nanomachine used to inject effectors into prokaryotic or eukaryotic cells and is thus involved in both host manipulation and interbacterial competition. The T6SS is widespread among Gram-negative bacteria, mostly within the Proteobacterium Phylum. This secretion system is commonly found in commensal and pathogenic plant-associated bacteria. Phylogenetic analysis of phytobacterial T6SS clusters shows that they are distributed in the five main clades previously described (group 1-5). The even distribution of the system among commensal and pathogenic phytobacteria suggests that the T6SS provides fitness and colonization advantages in planta and that the role of the T6SS is not restricted to virulence. This manuscript reviews the phylogeny and biological roles of the T6SS in plant-associated bacteria, highlighting a remarkable diversity both in terms of mechanism and function.
VI 型分泌系统 (T6SS) 是一种细菌纳米机器，用于将效应器注入原核或真核细胞，因此参与宿主操纵和细菌间竞争。T6SS 在革兰氏阴性菌中广泛存在，主要存在于变形菌门中。该分泌系统在共生和致病植物相关细菌中很常见。植物细菌 T6SS 簇的系统发育分析表明，它们分布在之前描述的五个主要分支（组 1-5）中。该系统在共生和致病植物细菌中的均匀分布表明，T6SS 在植物体内提供了适应性和定植优势，并且 T6SS 的作用不仅限于毒力。本文综述了与植物相关细菌中 T6SS 的系统发育和生物学作用，突出了在机制和功能方面的显著多样性。
