系统发育学作为预测耐药性传播工具的作用
The Role of Phylogenetics as a Tool to Predict the Spread of Resistance.
作者信息
Zhukova Anna, Cutino-Moguel Teresa, Gascuel Olivier, Pillay Deenan
机构信息
Unité Bioinformatique Evolutive, Centre de Bioinformatique, Biostatistique et Biologie Intégrative, C3BI USR 3756 Institut Pasteur et CNRS, France.
Virology Department, UCLH NHS Foundation Trust, London.
出版信息
J Infect Dis. 2017 Dec 1;216(suppl_9):S820-S823. doi: 10.1093/infdis/jix411.
Abstract
Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses.
摘要
在药物选择压力下，HIV的基因序列中会出现耐药性突变。耐药性能够传播。在本综述中，我们讨论了用于研究耐药性出现及耐药病毒传播的系统发育方法。
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