Grossman Zehava, Rico Sheryl-Vi, Cone Katherine, Shao Wei, Rehm Catherine, Jones Sara, Bozzi Giorgio, Dean Sophie, Dewar Robin, Rehman Tauseef, Purdy Julia, Hadigan Colleen, Pau Alice K, Maldarelli Frank
1 HIV Dynamics and Replication Program, NCI , NIH, Frederick, Maryland.
2 Sackler Faculty of Medicine, School of Public Health, Tel Aviv University , Tel Aviv, Israel .
AIDS Res Hum Retroviruses. 2018 Aug;34(8):680-684. doi: 10.1089/AID.2018.0041.
The presence of non-B HIV subtypes in the USA has been documented during the epidemic, although the timing of early introductions of different subtypes remains uncertain. Subtype C, the most common HIV variant worldwide, was first reported in the USA in 1996-97, after subtype C had expanded greatly in sub-Saharan Africa. In this study, we report a patient with subtype C infection acquired by mother-to-child transmission, born in the USA in 1990 to a Washington, D.C. resident who never traveled outside the USA, demonstrating that subtype C was present in the USA much earlier. Comparative analysis of the sequence from this patient and subtype C sequences in the USA and elsewhere suggest multiple independent introductions of this subtype into the USA have taken place, many of which are traced to sub-Saharan or East Africa. These data indicate subtype C HIV was already present in the USA years earlier than previously reported, and during the early period of subtype C expansion.
在美国，艾滋病流行期间已记录到非B型HIV亚型的存在，尽管不同亚型早期传入的时间仍不确定。C型是全球最常见的HIV变异株，在撒哈拉以南非洲地区大幅传播后，于1996 - 1997年首次在美国被报道。在本研究中，我们报告了一名1990年出生于美国的母婴传播C型感染患者，其母亲是华盛顿特区居民，从未出国旅行，这表明C型在美国出现的时间比之前认为的要早得多。对该患者序列与美国及其他地区C型序列的比较分析表明，该亚型已多次独立传入美国，其中许多可追溯到撒哈拉以南或东非地区。这些数据表明，C型HIV在美国出现的时间比之前报道的要早数年，且是在C型早期传播阶段。
