供应链在中低收入环境中预防人类免疫缺陷病毒耐药性方面的关键作用。
The Critical Role of Supply Chains in Preventing Human Immunodeficiency Virus Drug Resistance in Low- and Middle-Income Settings.
作者信息
Minior Thomas, Douglas Meaghan, Edgil Dianna, Srivastava Meena, Crowley John, Firth Jacqueline, Lapidos-Salaiz Ilana, Williams Jason, Lee Lana
机构信息
Office of HIV/AIDS, Global Health Bureau, United States Agency for International Development.
出版信息
J Infect Dis. 2017 Dec 1;216(suppl_9):S812-S815. doi: 10.1093/infdis/jix403.
Abstract
The functioning of the supply chain may be a driving factor behind the development of human immunodeficiency virus (HIV) drug resistance (HIVDR) in many low- and middle-income countries (LMICs). Additionally, the effectiveness of supply chains will likely impact the scale-up of both viral-load monitoring and HIVDR testing. This article describes the complexities of global supply chains relevant for LMICs and presents early data on stock-outs and drug substitutions in several countries supported by the US President's Emergency Plan for AIDS Relief. Supply chain systems will need to be strengthened to minimize interruptions as new antiretroviral therapy regimens are introduced and to facilitate adoption of new laboratory technologies.
摘要
在许多低收入和中等收入国家（LMICs），供应链的运作可能是人类免疫缺陷病毒（HIV）耐药性（HIVDR）发展背后的一个驱动因素。此外，供应链的有效性可能会影响病毒载量监测和HIVDR检测的扩大规模。本文描述了与LMICs相关的全球供应链的复杂性，并展示了由美国总统艾滋病紧急救援计划支持的几个国家的缺货和药物替代的早期数据。随着新的抗逆转录病毒治疗方案的引入，需要加强供应链系统，以尽量减少中断，并促进新实验室技术的采用。
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