先天淋巴细胞调控：遇见失散已久的表亲。

Innate Lymphoid Cell Regulation: Meeting the Long-Lost Cousin.

机构信息

Manchester Collaborative Centre for Inflammation Research (MCCIR), Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, M13 9PL, UK.

出版信息

Trends Immunol. 2017 Dec;38(12):873-874. doi: 10.1016/j.it.2017.09.003. Epub 2017 Oct 10.

DOI:10.1016/j.it.2017.09.003

PMID:29029958

Abstract

Innate lymphoid cells (ILCs) play critical roles in immune homeostasis and immunity to pathogens. Increasing evidence implicates dysregulated ILC responses as drivers of disease pathogenesis in multiple inflammatory disorders. A recent study reveals how inflammatory ILC responses can be suppressed by a newly defined subset of ILCs with regulatory function.

摘要

先天淋巴细胞 (ILC) 在免疫稳态和病原体免疫中发挥关键作用。越来越多的证据表明，ILC 反应失调是多种炎症性疾病发病机制的驱动因素。最近的一项研究揭示了具有调节功能的新型 ILC 亚群如何抑制炎症性 ILC 反应。