Peng Lei, Bonaguidi Michael A
Broad California Institute for Regenerative Medicine (CIRM) Center, University of Southern California Keck School of Medicine, Los Angeles, California; Department of Stem Cell Biology and Regenerative Medicine, Neuroscience Graduate Program, University of Southern California Keck School of Medicine, Los Angeles, California.
Broad California Institute for Regenerative Medicine (CIRM) Center, University of Southern California Keck School of Medicine, Los Angeles, California; Department of Stem Cell Biology and Regenerative Medicine, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California; Department of Gerontology, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California; Department of Biomedical Engineering, Zilkha Neurogenetic Institute, University of Southern California Keck School of Medicine, Los Angeles, California.
Am J Pathol. 2018 Jan;188(1):23-28. doi: 10.1016/j.ajpath.2017.09.004. Epub 2017 Oct 10.
The hippocampus is the only known brain region where physiological neurogenesis continues into adulthood across mammalian species and in humans. However, disease and injury can change the level of adult hippocampal neurogenesis, which plays an important role in regulating cognitive and emotional abilities. Alterations in hippocampal neurogenesis can mediate treatment of mental illness or affect the brain's capacity for repair and regeneration. In the present review, we evaluate how adult neurogenesis contributes to the repair and regeneration of hippocampal circuitry in the face of diseases and injuries. We also discuss possible future directions for harnessing adult neurogenesis for therapeutic use.
海马体是已知的唯一一个在成年期仍持续存在生理性神经发生的脑区，这一现象在所有哺乳动物物种以及人类中均存在。然而，疾病和损伤会改变成年海马体神经发生的水平，而成年海马体神经发生在调节认知和情感能力方面发挥着重要作用。海马体神经发生的改变能够介导精神疾病的治疗，或影响大脑的修复和再生能力。在本综述中，我们评估了成年神经发生在面对疾病和损伤时如何促进海马体神经回路的修复和再生。我们还讨论了利用成年神经发生进行治疗的未来可能方向。
