Center for Innovation in Brain Sciences, College of Medicine, Department of Pharmacology, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, United States.
Beckman Research Centre, Department of Experimental Therapeutics, City of Hope, Duarte, CA 91010, United States.
Adv Drug Deliv Rev. 2018 Jan 1;123:75-81. doi: 10.1016/j.addr.2017.10.003. Epub 2017 Oct 12.
Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be an exciting new therapy for treating chronic non-healing wounds such as diabetic ulcers, burns and cutaneous radiation burns. This review will focus on the use of MSCs to treat thermal and radiation burns. Large, severe burns are difficult to treat and pose a major public health burden worldwide. They are characterized by an extensive loss of the outer protective barrier, delayed wound healing, increased oxidative stress and a heightened inflammatory state. The breakdown of the protective barrier results in increased susceptibility to fluid loss and bacterial sepsis. In the case of radiation burns, chronic inflammation can result in subsequent waves of tissue injury leading to skin breakdown and necrosis. The aim of this review is to summarize the current knowledge on MSCs in treating thermal and radiation burns along with the specific scope of characterizing the biologic function of MSCs that help enhance wound healing in these chronic injuries.
间充质干细胞（MSCs）因其具有再生和抗炎表型而被开发用于多种适应症，并且同种异体移植对此类细胞类型是可行的，这一事实增强了其用途。动物研究和早期人类病例表明，这有可能成为治疗慢性难愈性伤口（如糖尿病溃疡、烧伤和皮肤放射性烧伤）的一种令人兴奋的新疗法。本综述将重点介绍 MSCs 治疗热烧伤和放射性烧伤的应用。大面积严重烧伤难以治疗，是全球范围内的一个主要公共卫生负担。它们的特点是大量失去外部保护屏障、延迟伤口愈合、氧化应激增加和炎症状态加剧。保护屏障的破坏导致对液体流失和细菌败血症的易感性增加。在放射性烧伤的情况下，慢性炎症会导致随后的组织损伤波，导致皮肤破裂和坏死。本综述的目的是总结 MSCs 治疗热烧伤和放射性烧伤的最新知识，以及表征有助于增强这些慢性损伤中伤口愈合的 MSCs 的生物学功能的具体范围。
