Lancet. 1988 Nov 5;2(8619):1039-43.
271 children born to HIV-infected mothers in 8 European centres are being followed up from birth in a multicentre, collaborative study. By June, 1988, 45% had been followed for over 1 year: 10 had developed AIDS or AIDS-related complex, all by the age of 9 months, of whom 5 had died. 22 other children had symptoms or signs suggestive of HIV infection; of these, 12 had immunological abnormalities, 9 of whom were infected. 5 children had problems not related to HIV, including 3 neonatal deaths. The other 234 children are immunologically normal and clinically well. The median age of antibody loss was 10.3 months, although 1 did not lose antibody until over 18 months. None lost antibody and then became and remained seropositive. Of 100 children followed for more than 15 months, 19 had persistent antibody, and 5 were antibody-negative but presumed to be infected because of virus isolation or antigen detection; these 5 children were clinically and immunologically normal. The estimated vertical transmission rate was 24%.
来自欧洲8个中心的271名感染艾滋病毒母亲所生的儿童，正在一项多中心合作研究中从出生起就接受随访。到1988年6月，45%的儿童已随访超过1年：10名儿童已发展为艾滋病或艾滋病相关综合征，均在9个月龄时发病，其中5名已死亡。另外22名儿童有提示艾滋病毒感染的症状或体征；其中12名有免疫异常，9名被感染。5名儿童有与艾滋病毒无关的问题，包括3例新生儿死亡。其他234名儿童免疫正常且临床状况良好。抗体消失的中位年龄为10.3个月，不过有1名儿童直到18个月后才失去抗体。没有儿童失去抗体后又转为并保持血清阳性。在随访超过15个月的100名儿童中，19名有持续抗体，5名抗体阴性但因病毒分离或抗原检测而被推测感染；这5名儿童临床和免疫状况正常。估计垂直传播率为24%。
