Zheng Qiushi, Bing Jian, Han Shiling, Guan Shuyun, Hu Tianren, Cai Lei, Chu Haiqing, Huang Guanghua
Shanghai Institute of Infectious Disease and Biosecurity, Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, PR China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
New Microbes New Infect. 2024 Oct 10;62:101506. doi: 10.1016/j.nmni.2024.101506. eCollection 2024 Dec.
Several human fungal pathogens, including drug-resistant and species of the complex, have emerged over the past two decades, posing new threats to human health. In this study, we report the isolation and identification of a novel species belonging to the genus , herein named as , from a clinical sputum sample of a COVID-19 patient. is phylogenetically closely related to fungal pathogens (syn. ) and . When grown on CHROMagar Plus medium, exhibited a similar coloration to strain CBS12372. was able to develop weak filaments on CM medium. Although and are phylogenetically closely related, comparative genomic and synteny analyses indicated significant chromosomal rearrangements between the two species. Although could not grow at 37 °C under regular culture condition, an increased fungal burden in the lung tissue of a mouse systemic infection model implies that it could be a potential opportunistic pathogenic yeast in humans.
在过去二十年中，出现了几种人类真菌病原体，包括耐药菌和复合体中的一些菌种，对人类健康构成了新的威胁。在本研究中，我们报告了从一名新冠肺炎患者的临床痰液样本中分离并鉴定出一种属于属的新物种，在此命名为。在系统发育上与真菌病原体（同义词为）和密切相关。当在CHROMagar Plus培养基上生长时，与菌株CBS12372表现出相似的颜色。能够在CM培养基上形成微弱的菌丝。虽然和在系统发育上密切相关，但比较基因组和共线性分析表明这两个物种之间存在显著的染色体重排。虽然在常规培养条件下不能在37°C生长，但在小鼠全身感染模型的肺组织中真菌负荷增加，这意味着它可能是人类潜在的机会致病性酵母。
