中国人群中使用西门子免疫比浊法检测IgG亚类的成人参考区间。
Adult reference intervals for IgG subclasses with Siemens immunonephelometric assays in Chinese population.
作者信息
Li Ping, Liu Zhongjuan, Wu Ziyan, Wen Xiaoting, Li Liubing, Zhang Shulan, Xu Yingchun, Li Yongzhe
机构信息
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100730 China.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China.
出版信息
Allergy Asthma Clin Immunol. 2017 Oct 5;13:44. doi: 10.1186/s13223-017-0216-7. eCollection 2017.
OBJECTIVE
To determine the adult reference intervals for the Siemens IgG subclass reagents.
METHODS
636 blood samples of healthy adults were analyzed to determine the level of IgG subclass using the reagents of Siemens immunonephelometric assay with molecular biology kits.
RESULTS
IgGSc reference intervals were as follows: IgG1 4.45-9.76 g/L, IgG2 2.07-8.57 g/L, IgG3 0.08-0.80 g/L and IgG4 0.05-1.54 g/L. There was an excellent correlation between the total IgG and the sum of the IgG subclasses. No significant gender and age differences were observed.
CONCLUSIONS
Our data provide the missing reference intervals and enable the use of the nephelometric IgG subclass reagents in Chinese. The study can offer reference on clinic diagnose.
目的
确定西门子IgG亚类试剂的成人参考区间。
方法
采用西门子免疫比浊法分子生物学试剂盒试剂，对636例健康成年人血液样本进行分析，以确定IgG亚类水平。
结果
IgG亚类参考区间如下：IgG1 4.45 - 9.76 g/L，IgG2 2.07 - 8.57 g/L，IgG3 0.08 - 0.80 g/L，IgG4 0.05 - 1.54 g/L。总IgG与IgG亚类总和之间存在良好的相关性。未观察到显著的性别和年龄差异。
结论
我们的数据提供了缺失的参考区间，并使免疫比浊法IgG亚类试剂能够在中国使用。该研究可为临床诊断提供参考。
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