脐血维生素D水平对早产儿新生儿败血症风险的影响。
Effects of cord blood vitamin D levels on the risk of neonatal sepsis in premature infants.
作者信息
Say Birgul, Uras Nurdan, Sahin Suzan, Degirmencioglu Halil, Oguz Serife Suna, Canpolat Fuat Emre
机构信息
Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
出版信息
Korean J Pediatr. 2017 Aug;60(8):248-253. doi: 10.3345/kjp.2017.60.8.248. Epub 2017 Aug 14.
PURPOSE
Vitamin D plays a key role in immune function. Vitamin D deficiency may play a role in the pathogenesis of infections, and low levels of circulating vitamin D are strongly associated with infectious diseases. In this study, we aimed to evaluate the effects of low vitamin D levels in cord blood on neonatal sepsis in preterm infants.
METHODS
One hundred seventeen premature infants with gestational age of <37 weeks were enrolled. In the present study, severe vitamin D deficiency (group 1) was defined as a 25-hydroxyvitamin D (25(OH)D) concentration <5 ng/mL; vitamin D insufficiency (group 2), 25(OH)D concentration ≥5 ng/mL and <15 ng/mL; and vitamin D sufficiency (group 3), 25(OH)D concentration ≥15 ng/mL.
RESULTS
Sixty-three percent of the infants had deficient levels of cord blood vitamin D (group 1), 24% had insufficient levels (group 2), and 13% were found to have sufficient levels (group 3). The rate of neonatal sepsis was higher in group 2 than in groups 1 and 3.
CONCLUSION
There was no significant relationship between the cord blood vitamin D levels and the risk of neonatal sepsis in premature infants.
目的
维生素D在免疫功能中起关键作用。维生素D缺乏可能在感染的发病机制中起作用，且循环维生素D水平低与传染病密切相关。在本研究中，我们旨在评估脐血中低维生素D水平对早产儿新生儿败血症的影响。
方法
纳入117例孕周<37周的早产儿。在本研究中，严重维生素D缺乏（第1组）定义为25-羟基维生素D（25(OH)D）浓度<5 ng/mL；维生素D不足（第2组），25(OH)D浓度≥5 ng/mL且<15 ng/mL；维生素D充足（第3组），25(OH)D浓度≥15 ng/mL。
结果
63%的婴儿脐血维生素D水平缺乏（第1组），24%的婴儿水平不足（第2组），13%的婴儿水平充足（第3组）。第2组新生儿败血症的发生率高于第1组和第3组。
结论
早产儿脐血维生素D水平与新生儿败血症风险之间无显著关系。
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