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本文引用的文献

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Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions.鼻内催产素对情绪解读与表达影响的荟萃分析
Neurosci Biobehav Rev. 2017 Jul;78:125-144. doi: 10.1016/j.neubiorev.2017.04.010. Epub 2017 Apr 30.
2
Effects of Intranasal Oxytocin on the Interpretation and Expression of Emotions in Anorexia Nervosa.鼻内注射催产素对神经性厌食症患者情绪解读与表达的影响
J Neuroendocrinol. 2017 Mar;29(3):n/a. doi: 10.1111/jne.12458.
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Low Fasting Oxytocin Levels Are Associated With Psychopathology in Anorexia Nervosa in Partial Recovery.低空腹催产素水平与神经性厌食症部分康复期的精神病理学有关。
J Clin Psychiatry. 2016 Nov;77(11):e1483-e1490. doi: 10.4088/JCP.15m10217.
4
Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing.催产素受体多态性和儿童期社会经历塑造成年人格、大脑结构和心理理论的神经相关性。
Neuroimage. 2016 Jul 1;134:671-684. doi: 10.1016/j.neuroimage.2016.04.009. Epub 2016 Apr 19.
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Severity of eating disorder symptoms related to oxytocin receptor polymorphisms in anorexia nervosa.神经性厌食症中与催产素受体基因多态性相关的饮食失调症状严重程度
Psychiatry Res. 2015 Aug 30;228(3):641-8. doi: 10.1016/j.psychres.2015.05.040. Epub 2015 Jun 11.
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Translational and therapeutic potential of oxytocin as an anti-obesity strategy: Insights from rodents, nonhuman primates and humans.催产素作为一种抗肥胖策略的转化和治疗潜力：来自啮齿动物、非人灵长类动物和人类的见解。
Physiol Behav. 2015 Dec 1;152(Pt B):438-49. doi: 10.1016/j.physbeh.2015.05.023. Epub 2015 May 23.
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Re-examining premature mortality in anorexia nervosa: a meta-analysis redux.重新审视神经性厌食症中的过早死亡率：一项元分析再探讨。
Compr Psychiatry. 2014 Nov;55(8):1773-84. doi: 10.1016/j.comppsych.2014.07.017. Epub 2014 Jul 22.
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Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism.催产素可改善自闭症患者推断他人社会情绪的行为和神经缺陷。
Brain. 2014 Nov;137(Pt 11):3073-86. doi: 10.1093/brain/awu231. Epub 2014 Aug 22.
9
Anorexia nervosa and its relation to depression, anxiety, alexithymia and emotional processing deficits.神经性厌食症及其与抑郁、焦虑、述情障碍和情绪加工缺陷的关系。
Eat Weight Disord. 2014 Jun;19(2):209-16. doi: 10.1007/s40519-014-0101-z. Epub 2014 Jan 29.
10
Exploring autistic traits in anorexia: a clinical study.探索厌食症中的自闭症特质：一项临床研究。
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低催产素水平与神经性厌食症中的述情障碍有关。

Low oxytocin levels are related to alexithymia in anorexia nervosa.

作者信息

Schmelkin Cindy, Plessow Franziska, Thomas Jennifer J, Gray Emily K, Marengi Dean A, Pulumo Reitumetse, Silva Lisseth, Miller Karen K, Hadjikhani Nouchine, Franko Debra L, Eddy Kamryn T, Lawson Elizabeth A

机构信息

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Eating Disorders Clinical and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

出版信息

Int J Eat Disord. 2017 Nov;50(11):1332-1338. doi: 10.1002/eat.22784. Epub 2017 Oct 16.

DOI:10.1002/eat.22784
PMID:29044580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5772992/
Abstract

OBJECTIVE

Anorexia nervosa is associated with social-emotional functioning deficits and low levels of the social neurohormone oxytocin, even after weight gain. The relationship between low oxytocin levels and social-emotional functioning impairment has not been studied.

METHOD

We performed a cross-sectional study of 79 women (19 who were less than 85% of ideal body weight [IBW] with anorexia nervosa [AN], 26 who were 90-120% IBW with a history of AN [AN-WR], and 34 who were 90-120% IBW with no eating disorder history [H]). We administered the Eating Disorder Examination-Questionnaire (EDE-Q), Leibowitz Social Anxiety Scale-Self Report (LSAS-SR), Dimensional Assessment of Personality Pathology-Basic Questionnaire (DAPP-BQ; suspiciousness and insecure attachment subscales), and the Toronto Alexithymia Scale (TAS-20). We also analyzed fasting serum oxytocin levels.

RESULTS

Most measures of social-emotional functioning showed impairment in women with AN and AN-WR compared to H. Oxytocin levels were low in AN-WR compared to H. Across groups, low oxytocin levels were associated with difficulty identifying feelings (r = -.45, p = .008) and overall alexithymia (r = -.34, p = .0489).

DISCUSSION

We speculate that low oxytocin levels may contribute to alexithymia in women with anorexia nervosa.

摘要

目的

神经性厌食症与社会情感功能缺陷以及社会神经激素催产素水平低有关，即使在体重增加后也是如此。催产素水平低与社会情感功能损害之间的关系尚未得到研究。

方法

我们对79名女性进行了一项横断面研究（19名体重低于理想体重[IBW]85%且患有神经性厌食症[AN]的女性，26名体重为IBW的90 - 120%且有神经性厌食症病史[AN - WR]的女性，以及34名体重为IBW的90 - 120%且无饮食失调病史[H]的女性）。我们发放了饮食失调检查问卷（EDE - Q）、莱博维茨社交焦虑量表 - 自我报告（LSAS - SR）、人格病理学维度评估 - 基本问卷（DAPP - BQ；怀疑和不安全依恋子量表）以及多伦多述情障碍量表（TAS - 20）。我们还分析了空腹血清催产素水平。

结果

与H组相比，AN组和AN - WR组女性的大多数社会情感功能指标均显示受损。与H组相比，AN - WR组的催产素水平较低。在所有组中，催产素水平低与难以识别情感（r = -0.45，p = 0.008）和整体述情障碍（r = -0.34，p = 0.0489）相关。

讨论

我们推测催产素水平低可能导致神经性厌食症女性出现述情障碍。