Wilcox A, Weinberg C, Baird D
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Lancet. 1988;2(8626-8627):1453-6. doi: 10.1016/s0140-6736(88)90933-6.
104 healthy women who had been attempting to become pregnant for three months were interviewed about their use of caffeinated beverages, alcohol, and cigarettes. In their subsequent cycles, women who consumed more than the equivalent of one cup of coffee per day were half as likely to become pregnant, per cycle, as women who drank less. A dose-response effect was present.
对104名试图怀孕三个月的健康女性进行了访谈,询问她们饮用含咖啡因饮料、酒精和吸烟的情况。在随后的周期中,每天饮用超过一杯咖啡的女性每个周期怀孕的可能性只有饮用较少咖啡的女性的一半。存在剂量反应效应。