Matis J, Krivjanská M
Institute of Virology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Acta Virol. 1988 Sep;32(5):379-85.
The ability of two strains of herpes simplex virus type 1 (HSZP and KOS) to shut off the host protein synthesis in the presence of Actinomycin D was investigated. The HSZP strain proved to be defective with respect to the so-called early shutoff function. In superinfection experiments, the HSZP was effective at interfering with the early shutoff function of the KOS strain provided that the HSZP infection preceded KOS superinfection. Heat inactivation of the HSZP did not lead to the loss of its interfering ability. Evidence was given that this interference was neither due to the hindrance of the KOS by HSZP at adsorption nor due its exclusion during penetration.
研究了两株1型单纯疱疹病毒（HSZP和KOS）在放线菌素D存在的情况下关闭宿主蛋白合成的能力。结果证明，HSZP菌株在所谓的早期关闭功能方面存在缺陷。在双重感染实验中，如果HSZP感染先于KOS双重感染，HSZP就能有效干扰KOS菌株的早期关闭功能。HSZP的热灭活不会导致其干扰能力的丧失。有证据表明，这种干扰既不是由于HSZP在吸附时对KOS的阻碍，也不是由于在穿透过程中的排斥。
