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1型单纯疱疹病毒（HSV-1）的HSZP在抗体中和后，也会干扰由HSV-1 KOS诱导的宿主蛋白合成早期关闭。

Herpes simplex virus type 1 (HSV-1) HSZP interferes also after antibody neutralization with early shutoff of host protein synthesis induced by HSV-1 KOS.

作者信息

Matis J, Krivjanská M, Rajcáni J

机构信息

Institute of Virology, Slovak Academy of Sciences, Bratislava, C.S.F.R.

出版信息

Arch Virol. 1992;123(1-2):209-14. doi: 10.1007/BF01317150.

DOI:10.1007/BF01317150
PMID:1312822
Abstract

The HSZP strain of herpes simplex virus type 1 (HSV-1) is defective with respect to the early shutoff of host protein synthesis. However, in superinfection experiments using Vero cells, the HSZP strain was effective, even after neutralization by antibody, at interfering with the early shutoff function of the HSV-1 KOS strain. Evidence was given that the observed interference was not due to exclusion of the KOS by HSZP at the level of adsorption or penetration. The neutralized KOS strain failed to induce early shutoff of host protein synthesis.

摘要

单纯疱疹病毒1型（HSV-1）的HSZP毒株在宿主蛋白合成的早期关闭方面存在缺陷。然而，在使用Vero细胞的超感染实验中，即使被抗体中和后，HSZP毒株仍能有效干扰HSV-1 KOS毒株的早期关闭功能。有证据表明，观察到的干扰并非由于HSZP在吸附或穿透水平上排除KOS所致。被中和的KOS毒株未能诱导宿主蛋白合成的早期关闭。

相似文献

1
Herpes simplex virus type 1 (HSV-1) HSZP interferes also after antibody neutralization with early shutoff of host protein synthesis induced by HSV-1 KOS.1型单纯疱疹病毒（HSV-1）的HSZP在抗体中和后，也会干扰由HSV-1 KOS诱导的宿主蛋白合成早期关闭。
Arch Virol. 1992;123(1-2):209-14. doi: 10.1007/BF01317150.
2
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Specific binding of herpes simplex virus type 1 (HSV-1) strain HSZP to host cell surface can provoke interference with early shutoff of host protein synthesis induced by HSV-1 strain KOS.单纯疱疹病毒1型（HSV-1）毒株HSZP与宿主细胞表面的特异性结合可引发对HSV-1毒株KOS诱导的宿主蛋白合成早期关闭的干扰。
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引用本文的文献

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Virus Genes. 1997;15(2):155-9. doi: 10.1023/a:1007915025086.
3
Cyclosporin A resistance of herpes simplex virus-induced "fusion from within" as a phenotypical marker of mutations in the Syn 3 locus of the glycoprotein B gene.

本文引用的文献

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The disaggregation of host polyribosomes in productive and abortive infection with herpes simplex virus.单纯疱疹病毒在增殖性感染和顿挫性感染中宿主多核糖体的解聚
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单纯疱疹病毒诱导的“从内部融合”对环孢菌素A的抗性作为糖蛋白B基因Syn 3位点突变的表型标记。
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Reproduction of freshly isolated and laboratory-maintained strains of human herpesvirus in cell cultures.人疱疹病毒新鲜分离株及实验室保存株在细胞培养中的增殖。
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Polysomes and protein synthesis in cells infected with a DNA virus.感染DNA病毒的细胞中的多核糖体与蛋白质合成
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Macromolecular synthesis in cells infected with herpes simplex virus.感染单纯疱疹病毒的细胞中的大分子合成
Nature. 1965 Jun 26;206(991):1374-5. doi: 10.1038/2061374a0.
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Degradation of cellular mRNAs induced by a virion-associated factor during herpes simplex virus infection of Vero cells.单纯疱疹病毒感染Vero细胞期间，病毒体相关因子诱导细胞mRNA降解。
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Anti-glycoprotein D antibodies that permit adsorption but block infection by herpes simplex virus 1 prevent virion-cell fusion at the cell surface.允许吸附但阻止单纯疱疹病毒1感染的抗糖蛋白D抗体可防止病毒体与细胞在细胞表面融合。
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