Matis J, Krivjanská M
Institute of Virology, Slovak Academy of Sciences, Bratislava.
J Gen Virol. 1994 Aug;75 ( Pt 8):2053-8. doi: 10.1099/0022-1317-75-8-2053.
The HSZP strain of herpes simplex virus type 1 (HSV-1) is defective with respect to the early shutoff of host protein synthesis but is effective at interfering with the early shutoff function of the HSV-1 KOS strain, even when heat-inactivated or neutralized by antibody. The interference was not due to exclusion of strain KOS by HSZP at the level of adsorption or penetration. The component responsible for the interference is an integral part of HSZP virions. Strain HSZP inactivated with zinc ions failed to interfere with the early shutoff function of the superinfecting strain KOS. The same effect was also found with strain HSZP purified from cells treated with 2-deoxy-D-glucose. This finding supports the idea that a specific interaction between HSZP virions and the cell surface can be responsible for the interference phenomenon.
1型单纯疱疹病毒（HSV-1）的HSZP毒株在宿主蛋白合成的早期关闭方面存在缺陷，但即使在热灭活或被抗体中和的情况下，它也能有效地干扰HSV-1 KOS毒株的早期关闭功能。这种干扰并非由于HSZP在吸附或穿透水平上排斥KOS毒株。负责干扰的成分是HSZP病毒粒子的一个组成部分。用锌离子灭活的HSZP毒株无法干扰超感染的KOS毒株的早期关闭功能。在用2-脱氧-D-葡萄糖处理的细胞中纯化得到的HSZP毒株也发现了同样的效果。这一发现支持了这样一种观点，即HSZP病毒粒子与细胞表面之间的特定相互作用可能是造成干扰现象的原因。
