Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Center for Complex Network Research and Department of Physics, Northeastern University, Boston, Massachusetts 02115, USA.
Sci Data. 2017 Oct 19;4:170156. doi: 10.1038/sdata.2017.156.
Lesioning studies have provided important insight into the functions of brain regions in humans and other animals. In the nematode Caenorhabditis elegans, with a small nervous system of 302 identified neurons, it is possible to generate lesions with single cell resolution and infer the roles of individual neurons in behaviour. Here we present a dataset of ~300 video recordings representing the locomotor behaviour of animals carrying single-cell ablations of 5 different motorneurons. Each file includes a raw video of approximately 27,000 frames; each frame has also been segmented to yield the position, contour, and body curvature of the tracked animal. These recordings can be further analysed using publicly-available software to extract features relevant to behavioural phenotypes. This dataset therefore represents a useful resource for probing the neural basis of behaviour in C. elegans, a resource we hope to augment in the future with ablation recordings for additional neurons.
损伤研究为理解人类和其他动物大脑区域的功能提供了重要的线索。在秀丽隐杆线虫（C. elegans）中，其神经系统较小，有 302 个确定的神经元，因此有可能实现单细胞分辨率的损伤，并推断单个神经元在行为中的作用。在这里，我们提供了一个约 300 个视频记录的数据集，这些视频记录代表了携带 5 种不同运动神经元单细胞消融的动物的运动行为。每个文件都包含大约 27000 帧的原始视频；每一帧都已分割，以获得被跟踪动物的位置、轮廓和身体曲率。这些记录可以使用公开可用的软件进一步分析，以提取与行为表型相关的特征。因此，该数据集代表了一个有用的资源，可用于探究秀丽隐杆线虫行为的神经基础，我们希望在未来通过对其他神经元的消融记录来扩充该资源。
