miRNA-146a多态性与中国患者头颈鳞状细胞癌易感性的关联：8项病例对照研究的荟萃分析

Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies.

作者信息

Zhang Silin, Hu Fangling, Liang Hongxing, Liu Yuanzhou, Yang Jianqiang, Zhou Wensheng

机构信息

Department of Otolaryngology, Shenzhen Hospital of Southern Medical University, Shenzhen, China.

Department of Otolaryngology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

PLoS One. 2017 Oct 19;12(10):e0186609. doi: 10.1371/journal.pone.0186609. eCollection 2017.

DOI:10.1371/journal.pone.0186609

PMID:29049342

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5648221/

Abstract

A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients. We retrieved databases and screened eligible papers up to March 10, 2017 and then we extracted the essential data. The subgroup analyses were also performed based on the tumor site, region, and genotyping means. Crude odds ratios (OR) at 95% confidence intervals (CI) were chosen to describe the strength of the association. As a result, 6 publications were included in our study which involved 8 independent case-control studies. A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs. GG: OR = 1.13; 95%CI = 1.00-1.29; CC vs. GG: OR = 1.19; 95%CI = 1.03-1.38]. According to the subgroup analysis based on tumor site, the risk of cancer was significantly increased among laryngeal cancer (dominant model: OR = 1.76, 95%CI = 1.26~~2.46, P = 0.001; homozygote model: OR = 1.83, 95%CI = 1.25~~2.67, P = 0.002) and nasopharyngeal carcinoma (homozygote model: OR = 1.41, 95%CI = 1.05~1.90, P = 0.022). In summary, variant alleles of miR-146a rs2910164 alleles may have an association with the increased risk of SCCHN in Chinese patients, and these associations differed based on tumor site. Further studies including a larger sample size will be necessary to clarify these results.

摘要

在一些分子流行病学研究中，已发现微小RNA-146a rs2910164多态性与头颈癌风险之间存在更密切的关联。最近进行了两项荟萃分析，以探讨miRNA-146a多态性与头颈部鳞状细胞癌（SCCHN）易感性之间的关系；然而，它们在种族差异的易感性方面得出了相互矛盾的结果。因此，本研究旨在阐明miRNA-146a rs2910164多态性与中国患者SCCHN发生风险之间的关系。我们检索了数据库，并筛选截至2017年3月10日的符合条件的论文，然后提取了关键数据。还根据肿瘤部位、地区和基因分型方法进行了亚组分析。选择95%置信区间（CI）的粗比值比（OR）来描述关联强度。结果，我们的研究纳入了6篇文献，其中涉及8项独立的病例对照研究。根据总体数据，发现miR-146a rs2910164多态性与中国患者SCCHN风险之间存在显著关联[CC+CG vs. GG：OR = 1.13；95%CI = 1.00 - 1.29；CC vs. GG：OR = 1.19；95%CI = 1.03 - 1.38]。根据基于肿瘤部位的亚组分析，喉癌（显性模型：OR = 1.76，95%CI = 1.26~~2.46，P = 0.001；纯合子模型：OR = 1.83，95%CI = 1.25~~2.67，P = 0.002）和鼻咽癌（纯合子模型：OR = 1.41，95%CI = 1.05~1.90，P = 0.022）患者的癌症风险显著增加。总之，miR-146a rs2910164等位基因的变异等位基因可能与中国患者SCCHN风险增加有关，并且这些关联因肿瘤部位而异。需要进一步开展包括更大样本量的研究来阐明这些结果。