Suppr超能文献

父母教育对后代的影响是受基因型偏倚还是调节?

Is the Effect of Parental Education on Offspring Biased or Moderated by Genotype?

作者信息

Conley Dalton, Domingue Benjamin W, Cesarini David, Dawes Christopher, Rietveld Cornelius A, Boardman Jason D

机构信息

New York University.

University of Colorado, Boulder.

出版信息

Sociol Sci. 2015;2(6):82-105. doi: 10.15195/v2.a6. Epub 2015 Feb 25.

Abstract

Parental education is the strongest measured predictor of offspring education, and thus many scholars see the parent-child correlation in educational attainment as an important measure of social mobility. But if social changes or policy interventions are going to have dynastic effects, we need to know what accounts for this intergenerational association, that is, whether it is primarily environmental or genetic in origin. Thus, to understand whether the estimated social influence of parental education on offspring education is biased owing to genetic inheritance (or moderated by it), we exploit the findings from a recent large genome-wide association study of educational attainment to construct a genetic score designed to predict educational attainment. Using data from two independent samples, we find that our genetic score significantly predicts years of schooling in both between-family and within-family analyses. We report three findings that should be of interest to scholars in the stratification and education fields. First, raw parent-child correlations in education may reflect one-sixth genetic transmission and five-sixths social inheritance. Second, conditional on a child's genetic score, a parental genetic score has no statistically significant relationship to the child's educational attainment. Third, the effects of offspring genotype do not seem to be moderated by measured sociodemographic variables at the parental level (but parent-child genetic interaction effects are significant). These results are consistent with the existence of two separate systems of ascription: genetic inheritance (a random lottery within families) and social inheritance (across-family ascription). We caution, however, that at the presently attainable levels of explanatory power, these results are preliminary and may change when better-powered genetic risk scores are developed.

摘要

父母的教育程度是所衡量的预测子女教育程度的最有力因素,因此许多学者将教育成就方面的亲子相关性视为社会流动性的一项重要指标。但是,如果社会变革或政策干预要产生代际影响,我们需要了解这种代际关联的成因,也就是说,其根源主要是环境因素还是基因因素。因此,为了了解父母教育程度对子女教育程度的估计社会影响是否因基因遗传而存在偏差(或受其调节),我们利用近期一项关于教育成就的大型全基因组关联研究的结果,构建了一个旨在预测教育成就的基因分数。利用来自两个独立样本的数据,我们发现在家庭间和家庭内分析中,我们的基因分数都能显著预测受教育年限。我们报告了三项分层和教育领域的学者可能感兴趣的研究结果。第一,教育方面原始的亲子相关性可能反映了六分之一的基因传递和六分之五的社会传承。第二,以孩子的基因分数为条件,父母的基因分数与孩子的教育成就没有统计学上的显著关系。第三,子代基因型的影响似乎不受父母层面所测量的社会人口统计学变量的调节(但亲子基因交互效应显著)。这些结果与存在两种独立的归因系统相一致:基因遗传(家庭内部的随机抽签)和社会传承(跨家庭归因)。然而,我们提醒,就目前可达到的解释力水平而言,这些结果是初步的,当开发出效力更强的基因风险分数时可能会发生变化。

相似文献

4
Institutional change and parental compensation in intergenerational attainment.代际获得中的制度变迁与父母补偿
Br J Sociol. 2018 Sep;69(3):601-625. doi: 10.1111/1468-4446.12293. Epub 2017 Aug 30.

引用本文的文献

3
Controlling for polygenic genetic confounding in epidemiologic association studies.控制流行病学关联研究中的多基因遗传混杂。
Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2408715121. doi: 10.1073/pnas.2408715121. Epub 2024 Oct 21.
9
10
Maximizing the value of twin studies in health and behaviour.最大化双胞胎研究在健康和行为中的价值。
Nat Hum Behav. 2023 Jun;7(6):849-860. doi: 10.1038/s41562-023-01609-6. Epub 2023 May 15.

本文引用的文献

2
Genomic assortative mating in marriages in the United States.美国婚姻中的基因组选型交配。
PLoS One. 2014 Nov 10;9(11):e112322. doi: 10.1371/journal.pone.0112322. eCollection 2014.
4
Genetic and educational assortative mating among US adults.美国成年人的遗传和教育匹配。
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):7996-8000. doi: 10.1073/pnas.1321426111. Epub 2014 May 19.
6
Genes can point to environments that matter to advance public health.基因能够指向对促进公众健康至关重要的环境因素。
Am J Public Health. 2013 Oct;103 Suppl 1(Suppl 1):S11-3. doi: 10.2105/AJPH.2013.301550. Epub 2013 Aug 8.
8
Genetics in population health science: strategies and opportunities.人群健康科学中的遗传学:策略与机遇。
Am J Public Health. 2013 Oct;103 Suppl 1(Suppl 1):S73-83. doi: 10.2105/AJPH.2012.301139. Epub 2013 Aug 8.
9
Genetic differential sensitivity to social environments: implications for research.遗传对社会环境的差异敏感性:对研究的启示。
Am J Public Health. 2013 Oct;103 Suppl 1(Suppl 1):S102-10. doi: 10.2105/AJPH.2013.301382. Epub 2013 Aug 8.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验