衰老过程中的脂肪组织炎症。
Adipose tissue inflammation in aging.
机构信息
Immunology Program, Michigan Medicine, United States.
Division of Geriatric and Palliative Medicine, Geriatrics Center, Michigan Medicine, United States.
出版信息
Exp Gerontol. 2018 May;105:27-31. doi: 10.1016/j.exger.2017.10.014. Epub 2017 Oct 18.
Abstract
Adipose tissue has traditionally been viewed as an organ of interest within studies of obesity and diet-associated metabolic disorders. However, as studies reveal the role white adipose tissue plays as an energy storage, a lipid metabolism site, and an adipokine secretor, it has become recognized as an organ of importance for metabolic health in both the young obese and the old obese. Within the realms of aging research, the pursuit of senolytics has taken the field's spotlight, where the clearance of senescent cells has shown to attenuate aspects of age-related disorders. More interestingly, these senolytics have also revealed that these senescent cells, specifically p16 cells, accumulate within adipose tissue, skeletal muscles, and eye (Baker et al., 2011). These results implicate the importance of adipose tissue inflammation in aging and widen the discussion on how senescent cells among other immune and non-immune cells cross paths to influence an organism's lifespan and healthspan.
摘要
脂肪组织在肥胖和饮食相关代谢紊乱的研究中一直被视为一个重要的研究对象。然而，随着研究揭示了白色脂肪组织作为能量储存、脂质代谢场所和脂肪细胞因子分泌者的作用，它已被认为是肥胖的年轻人和肥胖的老年人代谢健康的重要器官。在衰老研究领域，衰老细胞清除剂的研究成为了焦点，清除衰老细胞已被证明可以减轻与年龄相关的疾病的某些方面。更有趣的是，这些衰老细胞清除剂还表明，这些衰老细胞，特别是 p16 细胞，会在脂肪组织、骨骼肌和眼睛中积累（Baker 等人，2011 年）。这些结果表明脂肪组织炎症在衰老过程中的重要性，并拓宽了关于衰老细胞以及其他免疫和非免疫细胞如何相互作用影响生物体寿命和健康寿命的讨论。
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The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.代谢内质网应激传感器 IRE1α 抑制巨噬细胞的替代激活，并损害肥胖症中的能量消耗。
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ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity.内质网应激蛋白CHOP通过调节脂肪组织巨噬细胞极性介导胰岛素抵抗。
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