Leal Rodolfo Oliveira, Gil Solange
Centre Hospitalier Vétérinaire Fregis, 43 Av. Aristide Briand, Arcueil 94110, France.
Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA), Faculdade de Medicina, Veterinária, University of Lisbon (ULisbon), Av. Universidade Técnica, Lisbon 1300-477, Portugal.
Vet Sci. 2016 Oct 27;3(4):32. doi: 10.3390/vetsci3040032.
Type I interferons (IFNs) are well-known cytokines that, among their main functions, are key components of the host immune response against viral infections. Due to its immune modulation properties, they are commonly used in the therapeutic approach of various retroviral infections, namely human immunodeficiency virus (HIV) and feline immunodeficiency virus (FIV). In HIV infection, it has been shown that IFN therapy limits early viral replication, particularly useful on post-exposure prophylaxis. In veterinary medicine, recombinant feline interferon omega (rFeIFN-ω) was the first interferon licensed for use in cats. Several studies have recently shown that this compound seems to stimulate the innate immunity, decreasing clinical signs and co-infections in naturally FIV-infected cats. More than summarizing the main conclusions about rFeIFN-ω in cats, this review emphasizes the immune-modulation properties of IFN therapy, opening new perspectives for its use in retroviral infections. Either in FIV-infected cats or in HIV individuals, type I IFNs seem to induce an innate immune-modulation and should not be overlooked as a therapeutic option in retroviral infections.
I型干扰素（IFNs）是众所周知的细胞因子，在其主要功能中，是宿主针对病毒感染的免疫反应的关键组成部分。由于其免疫调节特性，它们常用于各种逆转录病毒感染的治疗方法，即人类免疫缺陷病毒（HIV）和猫免疫缺陷病毒（FIV）。在HIV感染中，已表明干扰素疗法可限制早期病毒复制，这在暴露后预防中特别有用。在兽医学中，重组猫ω干扰素（rFeIFN-ω）是第一种被许可用于猫的干扰素。最近的几项研究表明，这种化合物似乎能刺激先天免疫，减少自然感染FIV的猫的临床症状和合并感染。本综述不仅总结了关于rFeIFN-ω在猫身上的主要结论，还强调了干扰素疗法的免疫调节特性，为其在逆转录病毒感染中的应用开辟了新的前景。无论是在感染FIV的猫还是HIV感染者中，I型干扰素似乎都能诱导先天免疫调节，不应被忽视作为逆转录病毒感染的一种治疗选择。
