Department of Biomedical Sciences and Cornell Stem Cell Program, Cornell University, Ithaca, New York 14853, USA; email:
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Annu Rev Pathol. 2018 Jan 24;13:71-92. doi: 10.1146/annurev-pathol-020117-043935. Epub 2017 Oct 20.
Rapid advances in stem cell biology and regenerative medicine have opened new opportunities for better understanding disease pathogenesis and the development of new diagnostic, prognostic, and treatment approaches. Many stem cell niches are well defined anatomically, thereby allowing their routine pathological evaluation during disease initiation and progression. Evaluation of the consequences of genetic manipulations in stem cells and investigation of the roles of stem cells in regenerative medicine and pathogenesis of various diseases such as cancer require significant expertise in pathology for accurate interpretation of novel findings. Therefore, there is an urgent need for developing stem cell pathology as a discipline to facilitate stem cell research and regenerative medicine. This review provides examples of anatomically defined niches suitable for evaluation by diagnostic pathologists, describes neoplastic lesions associated with them, and discusses further directions of stem cell pathology.
干细胞生物学和再生医学的快速发展为更好地了解疾病发病机制和开发新的诊断、预后和治疗方法开辟了新的机会。许多干细胞龛位在解剖学上定义明确，因此可以在疾病发生和发展过程中对其进行常规的病理评估。评估干细胞中遗传操作的后果以及研究干细胞在再生医学和各种疾病（如癌症）发病机制中的作用，需要病理学方面的专业知识才能准确解释新发现。因此，迫切需要将干细胞病理学作为一个学科来促进干细胞研究和再生医学的发展。本综述提供了适合诊断病理学家评估的解剖定义明确的龛位的例子，描述了与这些龛位相关的肿瘤性病变，并讨论了干细胞病理学的进一步方向。
