Caries Res. 2017;51(6):590-595. doi: 10.1159/000479828. Epub 2017 Oct 24.
The aim of this study was to analyze the association between BMP2 (rs1884302) and DLX3 (rs2278163) gene polymorphisms and dental caries in primary and permanent dentitions. A total of 914 subjects were genotyped by the TaqMan methods: 176 caries-free children (with Decayed/Missing/Filled Teeth, DMFT = 0), 542 patients with dental caries in permanent dentition (DMFT ≥1), 83 caries-free children with primary teeth (with decayed/missing/filled teeth, dmft = 0), and 113 children with early childhood caries (ECC, dmft ≥1). There were no significant differences in allele/genotype frequencies between patients with caries in permanent dentition/ECC and caries-free children or between patients with very low (DMFT = 0-2), low (DMFT = 3-5), moderate (DMFT = 6-8), or high (DMFT ≥9) caries experience. Variability in BMP2 and DLX3 was not associated with caries in the Czech population.
本研究旨在分析 BMP2（rs1884302）和 DLX3（rs2278163）基因多态性与乳牙和恒牙龋齿之间的关联。采用 TaqMan 方法对 914 名受试者进行基因分型：176 名无龋儿童（Decayed/Missing/Filled Teeth，DMFT = 0），542 名恒牙龋齿患者（DMFT≥1），83 名无龋乳牙儿童（dmft = 0）和 113 名幼儿期龋患者（dmft≥1）。恒牙龋齿/幼儿期龋患者与无龋儿童或极低龋（DMFT = 0-2）、低龋（DMFT = 3-5）、中龋（DMFT = 6-8）或高龋（DMFT≥9）患者之间，等位基因/基因型频率无显著差异。在捷克人群中，BMP2 和 DLX3 的变异性与龋齿无关。
