捷克儿童维生素D受体TaqI基因多态性与龋齿
Vitamin D Receptor TaqI Gene Polymorphism and Dental Caries in Czech Children.
作者信息
Izakovicova Holla Lydie, Borilova Linhartova Petra, Kastovsky Jakub, Bartosova Michaela, Musilova Kristina, Kukla Lubomir, Kukletova Martina
机构信息
Clinic of Stomatology, Institutions Shared with St. Anne's Faculty Hospital, Masaryk University, Brno, Czech Republic.
出版信息
Caries Res. 2017;51(1):7-11. doi: 10.1159/000452635. Epub 2016 Nov 26.
AIM
We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries.
METHODS
A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method.
RESULTS
Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05).
CONCLUSIONS
In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.
目的
我们分析了患龋和未患龋儿童的维生素D受体TaqI（rs731236）基因多态性。
方法
采用TaqMan方法对总共388名受试者进行基因分型，其中153名无龋（龋失补牙数[DMFT]=0），235名患龋儿童（DMFT≥1）。
结果
虽然未检测到无龋和患龋儿童之间维生素D受体TaqI等位基因和基因型频率的显著差异，但发现这种多态性与牙龈炎之间存在显著关联（p<0.05）。
结论
与中国和土耳其之前的研究不同，维生素D受体TaqI基因变异不能用作识别患龋风险增加的捷克儿童的标志物。
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