González-Casamada Carlos, Molina-Frechero Nelly, Espinosa-Cristóbal León Francisco, García-López Salvador, Castañeda-Castaneira Enrique
Universidad Autónoma Metropolitana, Unidad Xochimilco, Maestría en Ciencias Odontológicas. Ciudad de México, México.
Universidad Autónoma Metropolitana, Unidad Xochimilco, Departamento de Atención a la Salud. Ciudad de México, México
Rev Med Inst Mex Seguro Soc. 2023 Jul 31;61(4):502-508. doi: 10.5281/zenodo.8200501.
Single nucleotide polymorphisms (SNPs) have been reported to play an important role in the etiology of dental caries. The aim of this research was, through a systematic review, to identify SNPs recently associated with dental caries in pediatric populations. We included studies performed in humans up to 18 years of age that evaluated the relationship between SNPs and dental caries from 2017 to 2022. Articles that covered other study variables were excluded. PubMed, ScienceDirect and Web of Science were used to search for information and the included articles were evaluated with one of the Joanna Briggs Institute's tools. Twenty-five articles were selected, 60% of which were given high methodological quality. A total of 10,743 research subjects, ranging in age from 20 months to 17 years, participated in the study. The SNPs considered risk factors were identified in the genes miRNA202, VDR, AMELX, TUFT1, KLK4, MBL2, ENAM, DEFB1, HLA-DRB1, TAS1R1, DSPP, RUNX2 and MMP13; those considered protective factors were identified in the genes MMP20, AMBN, MMP9, TIMP2, TNF-α, VDR, IL1B, ENAM and HLA-DRB1. This systematic review presents the genetic polymorphisms that are associated with the etiology of caries in children and adolescents, some of which act as risk factors and others as protective factors against the disease.
据报道，单核苷酸多态性（SNPs）在龋齿病因学中起重要作用。本研究的目的是通过系统评价，确定近期与儿童人群龋齿相关的单核苷酸多态性。我们纳入了对18岁及以下人群进行的研究，这些研究评估了2017年至2022年期间单核苷酸多态性与龋齿之间的关系。涵盖其他研究变量的文章被排除。使用PubMed、ScienceDirect和Web of Science搜索信息，并使用乔安娜·布里格斯研究所的工具之一对纳入的文章进行评估。共选择了25篇文章，其中60%的文章具有较高的方法学质量。共有10743名年龄在20个月至17岁之间的研究对象参与了该研究。在miRNA202、VDR、AMELX、TUFT1、KLK4、MBL2、ENAM、DEFB1、HLA-DRB1、TAS1R1、DSPP、RUNX2和MMP13基因中鉴定出被认为是危险因素的单核苷酸多态性；在MMP20、AMBN、MMP9、TIMP2、TNF-α、VDR、IL1B、ENAM和HLA-DRB1基因中鉴定出被认为是保护因素的单核苷酸多态性。本系统评价展示了与儿童和青少年龋齿病因相关的基因多态性，其中一些作为危险因素，另一些作为针对该疾病的保护因素。
