KLF4 在实体瘤中的预后意义：一项更新的荟萃分析。
Prognostic significance of KLF4 in solid tumours: an updated meta-analysis.
机构信息
Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University. National Clinical Research Center for Digestive Disease. Beijing Digestive Disease Center. Beijing Key Laboratory for Precancerous Lesion of Digestive Disease., Beijing, 100050, China.
Department of Oncology, The First Hospital of Fangshan District, Beijing, 102400, China.
出版信息
BMC Cancer. 2022 Feb 17;22(1):181. doi: 10.1186/s12885-022-09198-9.
BACKGROUND
Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues. Many studies have shown that KLF4 has various mechanisms in different tumours; however, the prognostic role of KLF4 remains unclear.
METHODS AND RESULTS
We searched the relevant literature that evaluated the prognostic value of KLF4 in different cancers, and the original survival data were obtained from the text, tables or Kaplan-Meier curves for both comparative groups. Thirty studies were included in this meta-analysis, and a total of 10 malignant tumours were involved. The expression of KLF4 was not associated with the prognosis for overall survival (hazard ratio(HR)0.86, 95% confidence interval (CI): 0.65-1.13, P = 0.28), disease-free survival/recurrence-free survival/metastasis-free survival (HR 0.87, 95% CI: 0.52-1.44, P = 0.58) or disease-specific survival (HR 1.13, 95% CI: 0.44-2.87, P = 0.8).
CONCLUSION
This study showed that the expression of KLF4 was not related to the prognosis of the tumours that were included in the study.
背景
Kruppel 样因子 4（KLF4）是一种富含锌指的转录因子，主要在终末分化的上皮组织中表达。许多研究表明，KLF4 在不同的肿瘤中有多种机制；然而，KLF4 的预后作用尚不清楚。
方法和结果
我们检索了评估 KLF4 在不同癌症中预后价值的相关文献，并从文本、表格或 Kaplan-Meier 曲线中获取了两个比较组的原始生存数据。这项荟萃分析共纳入 30 项研究，共涉及 10 种恶性肿瘤。KLF4 的表达与总生存预后无关（风险比（HR）0.86，95%置信区间（CI）：0.65-1.13，P=0.28）、无病生存/无复发生存/无转移生存（HR 0.87，95% CI：0.52-1.44，P=0.58）或疾病特异性生存（HR 1.13，95% CI：0.44-2.87，P=0.8）。
结论
本研究表明，在所纳入的研究中，KLF4 的表达与肿瘤的预后无关。
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