Reznicek Lukas, Burzer Sophie, Laubichler Andrea, Nasseri Ali, Lohmann Chris P, Feucht Nikolaus, Ulbig Michael, Maier Mathias
Department of Ophthalmology, Technical University of Munich, Munich 81675, Germany.
Int J Ophthalmol. 2017 Oct 18;10(10):1534-1538. doi: 10.18240/ijo.2017.10.09. eCollection 2017.
To evaluate and compare structural optical coherence tomography (OCT)-based parameters, such as Bruch's membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations.
Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals. All study participants underwent a full ophthalmic examination and VF testing with SAP. Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT. Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.
A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36 healthy right eyes of 36 individuals in the control group. Global MD of values correlated significantly with global RNFL (Pearson corr. coeff: 0.632, =0.001) and global BMO-MRW (Pearson corr. coeff: 0.746, <0.001) values in the glaucoma group. Global MD and sectorial RNFL or BMO-MRW values correlated less significantly. In the control group, MD values did not correlate with RNFL or BMO-MRW measurements. A subgroup analysis of myopic patients (>4 diopters) within the glaucoma group (=6) revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.
In a clinical setting, RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.
评估和比较基于结构光学相干断层扫描（OCT）的参数，如青光眼患者视野（VF）缺损时的布鲁赫膜开口最小边缘宽度（BMO-MRW）和视网膜神经纤维层（RNFL）厚度，并将两者与获得的标准色觉视野计（SAP）检查的平均偏差（MD）值相关联。
青光眼和青光眼性VF缺损患者纳入本前瞻性研究，并与年龄匹配的健康个体进行比较。所有研究参与者均接受全面眼科检查及SAP视野测试。使用谱域光学相干断层扫描（SD-OCT）获取视乳头周围RNFL厚度和BMO-MRW。计算获得的整体功能参数与整体及扇形结构参数之间的相关性分析。
纳入30例患者的30只青光眼右眼连续系列，并与对照组36例个体的36只健康右眼进行比较。青光眼组中，整体MD值与整体RNFL（Pearson相关系数：0.632，P = 0.001）和整体BMO-MRW（Pearson相关系数：0.746，P < 0.001）值显著相关。整体MD与扇形RNFL或BMO-MRW值的相关性较低。在对照组中，MD值与RNFL或BMO-MRW测量值不相关。青光眼组内近视患者（> 4屈光度）的亚组分析（n = 6）显示，MD与BMO-MRW之间的相关性高于MD与RNFL测量值之间的相关性。
在临床环境中，RNFL厚度和BMO-MRW与青光眼患者的整体VF敏感性相关性相似，BMO-MRW在近视性青光眼患者中显示出更高的相关性。
